Letter | Published:

What Abrogates Heart Transplant Rejection in Immunological Enhancement?

Naturevolume 247pages294297 (1974) | Download Citation



IMMUNOLOGICAL enhancement is historically the oldest method for impeding graft rejection. Such an outcome resulting from the injection of antiserum directed against a transplant seemed paradoxical, and the mechanism has been under discussion all through the years of study of antigens as putative tolerogens to the present time when immunological enhancement is the best available method for donor-specific immunosuppression in animal models1. The shortcomings of non-specific immunosuppression at present used in clinical transplantation are so great that an interpretation of the mechanism of immunological enhancement is important, in order to find how the method can best be adapted for clinical use.

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  1. 1

    French, M. E., and Batchelor, J. R., Transplant. Rev., 13, 115 (1972).

  2. 2

    Milton, J. D., Mowbray, J. F., Ruszkiewicz, M., and Carpenter, C. B., Transplantation, 15, 579 (1973).

  3. 3

    French, M. E., Transplant. Proc., 5, 621 (1973).

  4. 4

    Stuart, G. P., Fitch, F. W., and Rowley, D. A., Transplant. Proc., 2, 483 (1970).

  5. 5

    Yunis, E. J., and Amos, D. B., Proc. natn. Acad. Sci. U.S.A., 68, 3031 (1971).

  6. 6

    Benacerraf, B., and McDevitt, H. O., Science, N.Y., 175, 273 (1972).

  7. 7

    Bach, F. H., Widmer, M. B., Bach, M. L., and Klein, J., J. exp. Med., 136, 1430 (1972).

  8. 8

    Klein, J., and Park, J. M., J. exp. Med., 137, 1213 (1973).

  9. 9

    Livnat, S., Klein, J., and Bach, F. H., Nature new Biol., 243, 42 (1973).

  10. 10

    Ono, K., and Lindsay, E. S., J. Thoracic Cardiovasc. Surg., 57, 225 (1969).

  11. 11

    MacDonald, A. S., Davies, D. A. L., and Calne, R. Y., 4th Internat. Congress. Transpl. Abstr., 180 (Grune and Stratton, 1972).

  12. 12

    Diepenhost, P., Sprokholt, R., and Prins, H. K., Vox Sang., 23, 308 (1972).

  13. 13

    Hauptfeld, V., Klein, D., and Klein, J., Science, N.Y., 181, 167 (1973).

  14. 14

    Widmer, M. B., Alter, B. J., Bach, F. H., Bach, M. L., and Bailey, D. W., Nature new Biol., 242, 239 (1973).

  15. 15

    Eijsvoogel, V. P., DuBois, M. J. G. J., Melief, C. J. M., De Groot-Kooy, M. L., Koning, C., Van Rood, J. J., Van Leeuwen, A., DuToit, E., and Schellekens, P. T. L. A., in Histocompatibility Testing 1972 (Munksgaard, Copenhagen, 1973).

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  1. Searle Research Laboratories, High Wycombe

    • D. A. L. DAVIES


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