Letter | Published:

Reciprocal Relationship of Alkaline Phosphatase and 5′-Nucleotidase in Human Bone

Naturevolume 247pages286288 (1974) | Download Citation

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Abstract

THE presence in bone of alkaline phosphatase (APase, EC 3.1.3.1.; orthophosphoric monoester phosphohydrolase) has been known for many years1,2. Activity increases during bone growth1,3,4 and at the site of Paget's disease5,6, fractures7,8, fibrous dysplasia9, and various bone tumours5,7,9. Certain authors have suggested a positive role for APase in bone mineralisation1–3,10. Others have stressed its importance in bone matrix formation11. A third view emphasises the ability of APase to hydrolyse pyrophosphates, thereby relieving their inhibition of bone mineral formation12,13. Dissociation between APase activity and calcification has also been demonstrated14. The part played by APase in bone growth and mineralisation is thus controversial.

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References

  1. 1

    Robison, R., Biochem. J., 17, 286 (1923).

  2. 2

    Robison, R., and Soames, K. M., Biochem. J., 18, 740 (1924).

  3. 3

    Jibril, A. O., Biochim. biophys. Acta, 141, 605 (1967).

  4. 4

    Kuftinec, M. M., and Miller, S. A., Calc. Tiss. Res., 9, 173 (1972).

  5. 5

    Gutman, E. B., Sproul, E. E., and Gutman, A. B., Am. J. Cancer, 28, 485 (1936).

  6. 6

    Nagant de Deuxchaisnes, C., and Krane, S. M., Medicine (Baltimore), 43, 233 (1964).

  7. 7

    Timmer, J., Hadders, H. N., Hardonk, M. J., and Koudstaal, J., Br. J. Cancer, 22, 422 (1968).

  8. 8

    Semis, T. H., Gudmundson, C. R., Westlin, N. E., and Hallander, L. B., Clin. Chim. Acta, 31, 375 (1971).

  9. 9

    Jeffree, G. M., J. Bone Jt Surg., 54 B, 535 (1972).

  10. 10

    Teaford, M. E., and White, A. A., Proc. Soc. exp. Biol. Med., 117, 541 (1964).

  11. 11

    Kuhlman, R. E., J. Bone Jt Surg., 47 A, 545 (1965).

  12. 12

    Fleisch, H., and Russell, R. G. G., in Parathyroid Hormone, Thyrocalcitonin and Related Drugs (edit. by Rasmussen, H.), 61 (Pergamon Press, Oxford, 1970).

  13. 13

    Woltgens, J. H. M., Bonting, S. L., and Bijvoet, O. L. M., Clin. Orthop., 78, 296 (1971).

  14. 14

    Strates, B. S., Firschein, H. E., and Urist, M. R., Biochim. biophys. Acta, 244, 121 (1971).

  15. 15

    Reis, J. L., Biochem. J., 48, 548 (1951).

  16. 16

    Gibson, W., and Fullmer, H., J. Histochem. Cytochem., 14, 934 (1967).

  17. 17

    Mäkinen, K. K., and Pauio, I. K., Acta Chem. scand., 24, 3770 (1970).

  18. 18

    Belfield, A., and Goldberg, D. M., Nature, 219, 73 (1968).

  19. 19

    Goldberg, D. M., Goudie, R. B., and Ayre, H. A., J. clin. Endoc. Metab., 28, 41 (1968).

  20. 20

    Gornall, A. G., Bardawill, C. J., and David, M. M., J. biol. Chem., 177, 751 (1949).

  21. 21

    Siegal, S., Nonparametric Statistics for the Behavioral Sciences (McGraw-Hill, New York, 1956).

  22. 22

    Reid, E., in Enzyme Cytology (edit. by Roodyn, D. B.), 321 (Academic Press, New York, 1967).

  23. 23

    Vaes, G., and Jacques, P., Biochem. J., 97, 389 (1965).

  24. 24

    Bodansky, O., and Schwartz, M. K., Adv. clin. Chem., 11, 277 (1968).

  25. 25

    Goldberg, D. M., Digestion, 8, 87 (1973).

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Affiliations

  1. Department of Chemical Pathology, Royal Hospital, West Street, Sheffield, S1 3SR

    • D. M. GOLDBERG
    •  & A. BELFIELD

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https://doi.org/10.1038/247286a0

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