Abstract
THE presence in bone of alkaline phosphatase (APase, EC 3.1.3.1.; orthophosphoric monoester phosphohydrolase) has been known for many years1,2. Activity increases during bone growth1,3,4 and at the site of Paget's disease5,6, fractures7,8, fibrous dysplasia9, and various bone tumours5,7,9. Certain authors have suggested a positive role for APase in bone mineralisation1–3,10. Others have stressed its importance in bone matrix formation11. A third view emphasises the ability of APase to hydrolyse pyrophosphates, thereby relieving their inhibition of bone mineral formation12,13. Dissociation between APase activity and calcification has also been demonstrated14. The part played by APase in bone growth and mineralisation is thus controversial.
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GOLDBERG, D., BELFIELD, A. Reciprocal Relationship of Alkaline Phosphatase and 5′-Nucleotidase in Human Bone. Nature 247, 286–288 (1974). https://doi.org/10.1038/247286a0
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DOI: https://doi.org/10.1038/247286a0
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