Letter | Published:

Recovery of Yeast from Transient Inhibition of DNA Synthesis

Naturevolume 247pages275276 (1974) | Download Citation

Subjects

Abstract

IN the simple eukaryotic cell Saccharomyces cerevisiae nuclear division, cell division and the start of new budding cycles depend on DNA synthesis1. Protein synthesis is required for the recovery of new budding and cell division after transient exposure to hydroxyurea, a specific reversible inhibitor of DNA synthesis2. In this report I have attempted to answer two questions. (1) Does recovery of nuclear division require protein synthesis? (2) Does recovery of DNA synthesis itself require protein synthesis?

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Hartwell, L. H., J. molec. Biol., 59, 183 (1971).

  2. 2

    Slater, M. L., J. Bact., 113, 263 (1973).

  3. 3

    Williamson, D. H., Biochem. biophys. Res. Commun., 52, 731 (1973).

  4. 4

    Hereford, L. M., and Hartwell, L. H., Nature new Biol., 244, 129 (1973).

  5. 5

    Meuller, G. C., Fed. Proc., 28, 1780 (1969).

  6. 6

    Marunochi, T., and Messer, W., J. molec. Biol., 78, 211 (1973).

  7. 7

    Schneiderman, N. H., Dewey, W. C., and Highfield, D. P., Expl Cell Res., 67, 147 (1971).

  8. 8

    Littlefield, J. W., and Jacobs, P. S., Biochim. biophys. Acta, 108, 652 (1965).

  9. 9

    Taylor, E. W., Expl Cell Res., 40, 316 (1965).

  10. 10

    Cummins, J. E., and Rush, H. P., J. Cell Biol., 31, 577 (1966).

  11. 11

    Hartwell, L. H., Culotti, J., and Reid, B., Proc. natn. Acad. Sci. U.S.A., 66, 352 (1970).

  12. 12

    Culotti, J., and Hartwell, L. H., Expl. Cell Res., 67, 389 (1971).

  13. 13

    Tonino, G. J. M., and Rozijn, T. H., Biochim. biophys. Acta, 124, 427 (1966).

  14. 14

    Molenaar, I., Sillevis, W. W., Rozijn, T. H., and Tonino, G. J. M., Expl Cell Res., 60, 148 (1970).

  15. 15

    Hartwell, L. H., J. Bact., 104, 1280 (1970).

  16. 16

    Williamson, D. H., J. Cell Biol., 25, 517 (1965).

Download references

Author information

Affiliations

  1. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, 02111

    • M. L. SLATER

Authors

  1. Search for M. L. SLATER in:

About this article

Publication history

Received

Revised

Issue Date

DOI

https://doi.org/10.1038/247275a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.