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Carnosine in Nucleated Erythrocytes

Abstract

IN the course of studies of the metabolism of intracerebrally administered L-U-14C-histidine in brains of mice and frogs (Rana pipiens), analyses were also performed on blood samples from the injected animals. The mice received 1.5×106 c.p.m. of the labelled histidine, and 1 h later samples of blood were taken by means of orbital puncture. Frogs were injected with 2.9×106 c.p.m. and blood was obtained after 1 h by cardiac puncture. The samples were deproteinised in 5 volumes of 0.4 N perchloric acid and processed in the manner described previously for brain and tumour tissues1. Aliquots of neutralised extracts were electrophoresed on Whatman No. 3 paper at pH 10.0 together with known standards of carnosine, homocarnosine, histidine, imidazoleacetic acid, N-acetylhistidine, and histamine; and stained with Fast Red B in the manner described previously1.

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References

  1. Van Balgooy, J. N. A., Marshall, F. D., and Roberts, E., J. Neurochem., 19, 2341 (1972).

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BALGOOY, J., MARSHALL, F. & ROBERTS, E. Carnosine in Nucleated Erythrocytes. Nature 247, 226–227 (1974). https://doi.org/10.1038/247226a0

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