Letter | Published:

Morphine-induced Suppression of Voluntary Alcohol Drinking in Rats

Naturevolume 246pages425427 (1973) | Download Citation



A DEBATE has arisen over whether there is a relationship between alcohol and morphine addictions. With the classical phenomena associated with addiction there is little or no evidence for a connection between the two drugs1–4. The short-term effects are different, the withdrawal symptoms are different, morphine antagonists do not precipitate withdrawal in alcohol-dependent animals, and usually no cross-dependencies or cross-tolerances have been found, although there are reports of increased tolerance for morphine in mice that have been habituated to alcohol5 and in some human alcoholics6.

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  1. 1

    Goldstein, A., and Judson, B. A., Science, N.Y., 172, 290 (1971).

  2. 2

    Haluska, P. V., and Hoffman, P. C., Science, N.Y., 169, 1104 (1970).

  3. 3

    Seevers, M. H., Science, N.Y., 170, 113 (1972).

  4. 4

    Stolerman, I. P., Kumar, R., and Steinberg, H., Psychopharmacologia, 20, 321 (1971).

  5. 5

    Venho, I., Eerola, R., Venho, E. V., and Vartiainen, O., Ann. Med. exp. Biol. Fenn., 33, 249 (1955).

  6. 6

    Seevers, M. H., and Deneau, G. A., in Physiological Pharmacology (edit. by Root, W. S., and Hofmann, F. G.), 565 (Academic, New York, 1963).

  7. 7

    Isbell, H., Fraser, H. F., Wikler, A., Belleville, R. E., and Eisenman, A. J., Q. Jl Stud. Alc., 16, 1 (1955).

  8. 8

    Kalant, H., and Dews, P. E., in Experimental Approaches to the Study of Drug Dependence (edit. by Kalant, H., and Hawkins, R. D.), 109 (Univ. of Toronto Press, Toronto, 1969).

  9. 9

    Nichols, J., and Hsiao, S., Science, N.Y., 157, 561 (1967).

  10. 10

    Eriksson, K., and Kiianmaa, K., Ann. Med. exp. Biol. Fenn., 49, 73 (1972).

  11. 11

    LeMagnen, J., J. Physiol., Paris, 52, 873 (1960).

  12. 12

    Sinclair, J. D., and Senter, R. J., Psychon. Sci., 8, 11 (1967).

  13. 13

    Sinclair, J. D., and Senter, R. J., Q. Jl Stud. Alc., 29, 863 (1968).

  14. 14

    Sinclair, J. D., Q. Jl Stud. Alc., 33, 769 (1972).

  15. 15

    Sinclair, J. D., Psychon. Sci., 25, 21 (1971).

  16. 16

    Sinclair, J. D., Walker, S., and Jordan, B., Q. Jl Stud. Alc. (in the press).

  17. 17

    Parker, L., Failor, A., and Weidman, K., J. comp. physiol. Psychol., 82, 294 (1973).

  18. 18

    Maier, S. F., Zahorik, D. M., and Albin, R. W., J. comp. physiol. Psychol., 74, 254 (1971).

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  1. Research Laboratories of the State Alcohol Monopoly (ALKO), 00101, Helsinki, 10

    • J. D. SINCLAIR
  2. Department of Psychology, Sangamon State University, Springfield, Illinois

    • J. ADKINS
  3. Department of Psychology, University of Oregon, Eugene, Oregon



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