Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Abrogation of Lymphocyte Trapping by Ascitic Tumours

Abstract

SEQUESTRATION of lymphocytes within antigen-stimulated lymphoid organs is observed regularly following injection of immunogens and adjuvants1–5. This lymphoid “trapping” is one of the earliest events in immunization and may be necessary for the expression of an effective immune response. The mechanism responsible for controlling the operation of the “trap” is incompletely understood but must relate to the way in which lymphocytes normally recirculate.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Frost, P., and Lance, E. M., Immunology (in the press).

  2. Frost, P., and Lance, E. M., in Ciba Symposium—Immunopotentiation (edit. by Wolstenholme, G. C. W., and Knight, J.) (Churchill, London, in the press).

  3. Zatz, M., and Lance, E. M., J. exp. Med., 134, 274 (1971).

    Article  Google Scholar 

  4. Dresser, D. W., Taub, R. N., and Krantz, G. A. R., Immunology, 18, 663 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Ford, W. L., Immunology, 15, 609 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Southam, C. N., Cancer Res., 25, 1433 (1968).

    Google Scholar 

  7. Harris, J., and Bagai, R. C., Med. Clins. N. Am., 56, 501 (1972).

    Article  CAS  Google Scholar 

  8. Biano, G., Braun, B. L., Jones, E. E., and Rosenoer, V. M., Proc. Soc. exp. Biol. Med., 136, 507 (1971).

    Article  CAS  Google Scholar 

  9. Zatz, M., and Lance, E. M., Nature new Biol., 234, 253 (1971).

    Article  CAS  Google Scholar 

  10. Yamazaki, H., Nitta, K., and Umezawa, H., Gann, 64, 83 (1973).

    CAS  PubMed  Google Scholar 

  11. Chan, C. L., and Sinclair, N. R. St C., J. natn. Cancer Inst., 48, 1829 (1972).

    Google Scholar 

  12. Apfel, C. A., Arnason, B. G., Twinam, C. W., and Harris, C. A., Br. J. Cancer, 20, 122 (1966).

    Article  Google Scholar 

  13. Groshman, J., and Nowotny, A., J. Immun., 109, 1090 (1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

FROST, P., LANCE, E. Abrogation of Lymphocyte Trapping by Ascitic Tumours. Nature 246, 101–103 (1973). https://doi.org/10.1038/246101a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/246101a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing