Abstract
IN the deuterostomes, RNA previously synthesized in the oocyte or on maternal genetic templates is required for development of the embryo through the blastula1,2. In sea urchin3, amphibian4,5 and fish6–8 zygotes early and continuous exposure to actinomycin D resulted in blastula arrest. Removal of the drug before the third cleavage in the sea urchin allowed normal development through gastrulation9 although in the fish6, in spite of a similar removal, gastrulation is abnormal and surviving embryos are defective. Further development awaits a switch to the immediacy of nucleus-directed RNA synthesis. Information necessary for gastrulation is synthesized during cleavage stages and appears to be stored before it is utilized10,11.
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SCHWARTZ, R., WILDE, C. Changes in Protein Synthesis in the Morphogenesis of Fundulus heteroclitus. Nature 245, 376–379 (1973). https://doi.org/10.1038/245376a0
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DOI: https://doi.org/10.1038/245376a0
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