Effect of Neuraminidase Pretreatment on the Susceptibility of Normal and Transformed Mammalian Cells to Bovine Enterovirus 261

Abstract

TAYLOR et al. reported regression of ascites and solid tumours in mice inoculated with bovine enterovirus ¹ (BEV-1)¹ without any observable pathological effect on the animals. The basis of the oncolytic specificity was associated with the adsorption spectrum of the virus^2,3. The specificity was also expressed in vitro since virus transformed and oncogenic cells were susceptible to BEV-1, in contrast to cells of un-transformed lines and of primary cultures, which were resistant⁴.