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Antigenic Differences between Isolates of Swine Vesicular Disease Virus and their Relationship to Coxsackie B5 Virus

Abstract

THERE have been several outbreaks of a vesicular disease in swine in which the causative agent was shown to be an enterovirus1–3. The first occurred in Italy in 19661 and this was followed by an outbreak in Hong Kong in 19712. A more serious and widespread outbreak occurred in the United Kingdom during the winter of 1972-733 and several other cases were reported in Austria, France, Italy and Poland during the same period. Further cases also occurred in the United Kingdom in June 1973. From an epidemiological point of view it was important to know whether the same strain of virus had caused the disease in the different countries. Differences between some isolates could be demonstrated by complement fixation tests using specific antisera prepared in guinea pigs (Arrowsmith, A., personal communication) and by cross-neutralization tests using sera from convalescent swine (ref. 2 and R. B., Mann, J. A., and Goodridge, D., unpublished). We show here that unequivocal antigenic differences between some of the isolates can be demonstrated by immunodiffusion tests.

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References

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BROWN, F., TALBOT, P. & BURROWS, R. Antigenic Differences between Isolates of Swine Vesicular Disease Virus and their Relationship to Coxsackie B5 Virus. Nature 245, 315–316 (1973). https://doi.org/10.1038/245315a0

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