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Low and High Affinity Antibodies Can Alternate during the Immune Response

Nature volume 245, pages 263–264 (1973)Cite this article

Abstract

ANTIBODY affinity usually varies during the course of the immune response. This information has been acquired by studying antibodies present in the serum (for review see ref. 1), released by single cells in semi-solid media2–10 or, more recently, synthesized in vitro and released into liquid medium by lymph node microfragments11,12.

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References

  1. Siskind, G. W., and Benacerraf, B., Adv. Immun., 10, 1 (1969).

    Article  CAS  Google Scholar 

  2. Andersson, B., J. expl. Med., 132, 77 (1970).

    Article  CAS  Google Scholar 

  3. Andersson, B., J. expl. Med., 135, 312 (1972).

    Article  CAS  Google Scholar 

  4. Claflin, L., and Merchant, B., Cell. Immun., 5, 209 (1972).

    Article  CAS  Google Scholar 

  5. Claflin, L., Merchant, B., and Inman, J., J. Immun., 110, 241 (1973).

    CAS  PubMed  Google Scholar 

  6. Claflin, L., and Merchant, B., J. Immun., 110, 252 (1973).

    CAS  PubMed  Google Scholar 

  7. Dona, G., Schiaffini, G., Garavini, M., and Mancini, C., J. Immun., 109, 1245 (1972).

    Google Scholar 

  8. Huchet, R., and Feldmann, M., Eur. J. Immun., 3, 49 (1973).

    Article  CAS  Google Scholar 

  9. Miller, G. W., and Segre, D., J. Immun., 109, 74 (1972).

    CAS  PubMed  Google Scholar 

  10. Wu, C. Y., and Cinader, B., Eur. J. Immun., 2, 398 (1972).

    Article  CAS  Google Scholar 

  11. Macario, A. J. L., Conway de Macario, E., Franceschi, C., and Celada, F., in Advances in Experimental Medicine and Biology (edit. by Lindahl-Kiessling, K., Aim, G., and Hanna, jun., M. G.), 12, 365 (Plenum Press, New York and London, 1971).

    Google Scholar 

  12. Macario, A. J. L., Conway de Macario, E., Franceschi, C., and Celada, F., J. expl. Med., 136, 353 (1972).

    Article  CAS  Google Scholar 

  13. Eisen, H. N., and Siskind, G. W., Biochemistry, 3, 996 (1964).

    Article  CAS  Google Scholar 

  14. Steiner, L. A., and Eisen, H. N., Bact. Rev., 30, 383 (1966).

    CAS  PubMed  Google Scholar 

  15. Steiner, L. A., and Eisen, H. N., J. expl. Med., 126, 1161 (1967).

    Article  CAS  Google Scholar 

  16. Goidl, E. A., Paul, W. E., Siskind, G. W., and Benacerraf, B., J. Immun., 100, 371 (1968).

    CAS  PubMed  Google Scholar 

  17. Urbain, J., van Acker, A., de Vos-Cloetens, C., and Urbain-Vasanten, G., Immunochemistry, 9, 121 (1972).

    Article  CAS  Google Scholar 

  18. Werblin, T. P., and Siskind, G. W., Immunochemistry, 9, 978 (1972).

    Article  Google Scholar 

  19. Werblin, T. P., Kim, Y. T., Quagliata, F., and Siskind, G. W., Immunology, 24, 477 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Gopalakrishnan, P. V., Hughes, W. S., Kim, Y., and Karush, F., Immunochemistry, 10, 191 (1973).

    Article  CAS  Google Scholar 

  21. Haber, E., and Stone, M., Israel J. med. Sci., 5, 332 (1969).

    CAS  PubMed  Google Scholar 

  22. Montgomery, P. C., Rockey, J. H., and Williamson, A. R., Proc. natn. Acad. Sci. U.S.A., 69, 228 (1972).

    Article  ADS  CAS  Google Scholar 

  23. Kitagawa, M., Grossberg, A. L., Yagi, Y., and Pressman, D., Immunochemistry, 4, 157 (1967).

    Article  CAS  Google Scholar 

  24. Roholt, O. A., Seon, B. K., and Pressman, D., Immunochemistry, 7, 329 (1970).

    Article  CAS  Google Scholar 

  25. Macario, A. J. L., Conway de Macario, E., and Celada, F., Nature new Biol., 241, 22 (1973).

    Article  CAS  Google Scholar 

  26. Jaton, J. C., Waterfield, M. D., Margolies, M. M., Bloch, K. J., and Haber, E., Biochemistry, 10, 1583 (1971).

    Article  CAS  Google Scholar 

  27. Kimball, J. W., Immunochemistry, 9, 1169 (1972).

    Article  CAS  Google Scholar 

  28. Macario, A. J. L., Conway de Macario, E., and Celada, F., Immunology, 24, 237 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Celada, F., Macario, A. J. L., and Conway de Macario, E., Immunochemistry (in the press).

  30. Rotman, B., and Celada, F., Proc. natn. Acad. Sci. U.S.A., 60, 660 (1968).

    Article  ADS  CAS  Google Scholar 

  31. Celada, F., Ellis, J., Bodlund, K., and Rotman, B., J. expl. Med., 134, 751 (1971).

    Article  CAS  Google Scholar 

  32. Celada, F., Strom, R., and Bodlund, K., in The Lactose Operon (edit. by Beckwith, J. R., and Zipser, D.), 291 (Cold Spring Harbor Laboratories Press, Cold Spring Harbor, N.Y., 1970).

    Google Scholar 

  33. Britton, S., Wepsic, T., and Moller, G., Immunology, 14, 491 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Askonas, B. A., and Williamson, A. R., Nature, 238, 339 (1972).

    Article  ADS  CAS  Google Scholar 

  35. Davie, J. M., and Paul, W. E., J. expl. Med., 135, 660 (1972).

    Article  CAS  Google Scholar 

  36. Segre, D., and Segre, M. (in the press).

  37. Feldmann, M., and Basten, A., Eur. J. Immun., 2, 213 (1972).

    Article  CAS  Google Scholar 

  38. Feldmann, M., and Nossal, G. J. V., Q. Rev. Biol., 47, 269 (1972).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cell Biology, Via Romagnosi 18/A, 00196, Rome

    ALBERTO J. L. MACARIO & EVERLY CONWAY DE MACARIO

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  1. ALBERTO J. L. MACARIO
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  2. EVERLY CONWAY DE MACARIO
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MACARIO, A., CONWAY DE MACARIO, E. Low and High Affinity Antibodies Can Alternate during the Immune Response. Nature 245, 263–264 (1973). https://doi.org/10.1038/245263a0

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