Abstract
IT has been suggested that “drug” strains and “non-drug” strains of Cannabis sativa L. comprise two comprehensive groups1,2, which can be identified on the basis of their relative content of two of the principal “cannabinoids”. Drug strains have been thought to contain an excess, usually substantial, of (—)-Δ9-trans-tetrahydrocannabinol (Δ9-THC) in comparison with the amount of cannabidiol (CBD), including carboxylate forms of both compounds, and non-drug strains have been held to have the reverse ratio. The former compound is considered psychotomimetic (psychosis-imitating), whereas the latter is not3. In examining the above cannabinoid ratio to decide in which phenotypic group a strain belongs, some investigators2 add the amount of cannabinol (CBN) to the amount of THC. The former seems to be an oxidation product of Δ9-THC (ref. 4) and is not considered to be psychoactive.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fetterman, P. S., Keith, E. S., Waller, C. W., Guerrero, O., Doorenbos, N. J., and Quinby, M. W., J. pharm. Sci., 60, 1246 (1971).
Toffoli, F., Avico, V., and Signoretti-Ciranni, E., Bull. Narcot., 20, 55 (1968).
Mechoulam, R., Science, N. Y., 168, 1159 (1970).
Levine, J., J. Am. chem. Soc., 66, 1868 (1944).
De Faubert Maunder, M. J., J. Ass. Public Anal., 8, 42 (1970).
Korte, F., Sieper, H., and Tira, S., Bull. Narcot., 17, 35 (1965).
Turner, C. E., and Hadley, K., J. pharm. Sci. (in the press).
Yamauchi, T., Shoyama, Y., Matsuo, Y., and Nishioka, I., Chem. pharm. Bull. Tokyo, 16, 1164 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SMALL, E., BECKSTEAD, H. Cannabinoid Phenotypes in Cannabis sativa. Nature 245, 147–148 (1973). https://doi.org/10.1038/245147a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/245147a0
This article is cited by
-
High-throughput methods to identify male Cannabis sativa using various genotyping methods
Journal of Cannabis Research (2022)
-
Semi-quantitative analysis of cannabinoids in hemp (Cannabis sativa L.) using gas chromatography coupled to mass spectrometry
Journal of Cannabis Research (2022)
-
Beyond Δ9-tetrahydrocannabinol and cannabidiol: chemical differentiation of cannabis varieties applying targeted and untargeted analysis
Analytical and Bioanalytical Chemistry (2022)
-
Factors that Impact the Pharmacokinetic and Pharmacodynamic Effects of Cannabis: a Review of Human Laboratory Studies
Current Addiction Reports (2022)
-
Cannabis with breast cancer treatment: propitious or pernicious?
3 Biotech (2022)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.