Abstract
It is suggested that cellular differentiation is established during development by the development of higher order structural polymorphism of the chromosomes. The differentiated superstructure, once adopted, would be maintained during replication.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gurdon, J. B., and Laskey, R. A., J. Embryol. exp. Morphol., 24, 227 (1970).
Lyon, M. F., Phil. Trans. R. Soc., B, 259, 41 (1970).
Lyon, M. F., Nature new Biol., 232, 229 (1971).
Lyon, M. F., Biol Rev., 47, 1 (1972).
Brown, S. W., and Chandra, H. S., Proc. natn. Acad. Sci. U.S.A., 70, 195 (1973).
Jacob, F., and Monod, J., J. molec. Biol., 3, 318 (1961).
Monod, J., and Jacob, F., Cold Spring Harbor Symp. quant. Biol., 26, 389 (1961).
Britten, R. J., and Davisdson, E. H., Science, N.Y., 165, 249 (1969).
Eicher, E. M., Adv. Genetics, 15, 175 (1971).
Siniscalco, M., Klinger, H. P., Eagle, H., Koprowski, H., Fujimoto, W. Y., and Seegmiller, J. E., Proc. natn. Acad. Sci. U.S.A., 62, 793 (1969).
Migeon, B. R., Nature, 239, 87 (1972).
Ohno, S., Nature, 234, 134 (1971).
Pardon, J. F., and Wilkins, M. H. F., J. molec. Biol., 68, 115 (1972).
Crick, F. H. C., Nature, 234, 25 (1971).
Paul, J., Nature, 238, 444 (1972).
Gall, J. G., Brookhaven Symp. Biol., 8, 17 (1955).
Alberts, B. M., and Frey, L., Nature, 227, 1313 (1970).
Wang, J. C., J. molec. Biol., 55, 523 (1971).
Champoux, J. J., and Dulbecco, R., Proc. natn. Acad. Sci. U.S.A., 69, 143 (1972).
Eason, R., and Vinograd, J., J. Virol., 7, 1 (1971).
Barr, M. L., Expl Cell Res., 2, 288 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cook, P. Hypothesis on Differentiation and the Inheritance of Gene Superstructure. Nature 245, 23–25 (1973). https://doi.org/10.1038/245023a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/245023a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
