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Effects of Antibodies to Luteinizing Hormone–Releasing Hormone in the Male Rabbit and on the Rat Oestrous Cycle

Nature volume 244, pages 160–161 (1973)Cite this article

Abstract

PITUITARY gonadotrophin secretion is stimulated by luteinizing hormone-releasing hormone (LH–RH) from hypothalamic extracts1. The synthetic compound has similar effects, releasing luteinizing hormone and follicle stimulating hormone in rats2,3 and humans4. Selective neutralization of this releasing hormone, for example, by a specific antibody, would be important in the study of its action. Although this method has been used to neutralize other hormones5, they were acting through the systemic circulation, unlike the releasing hormones which act via the localized hypothalamic-pituitary portal system.

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Authors and Affiliations

  1. Department of Surgery, The University, Dundee,

    HAMISH M. FRASER & ANDREW GUNN

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  1. HAMISH M. FRASER
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  2. ANDREW GUNN
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FRASER, H., GUNN, A. Effects of Antibodies to Luteinizing Hormone–Releasing Hormone in the Male Rabbit and on the Rat Oestrous Cycle. Nature 244, 160–161 (1973). https://doi.org/10.1038/244160a0

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