Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Experimental Model for von Willebrand's Disease


IT has been reported1 that Ristocetin induces aggregation of platelets in normal platelet-rich plasma (PRP) but not of platelets from patients with von Willebrand's disease. Results presented here demonstrate that the aggregation of platelets induced by Ristocetin involves a factor present in normal and haemophilia A plasma and absent in Willebrand plasma. Lack of such a factor would then explain the inability of platelets to aggregate in response to Ristocetin in von Wille-brand's disease. In eight patients fulfilling the criteria of von Willebrand's disease (Table 1), platelet aggregation induced by Ristocetin was markedly deficient when compared to healthy normal plasmas or did not occur at all. The abnormal responses of platelets from von Willebrand's patients could be corrected by the addition of small volumes of normal platelet-poor plasma (PPP) (Fig. 1); similar correction was achieved by Haemophilia A PPP but not by PPP from patients with von Willebrand's disease.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Howard, M. A., and Firkin, B. G., Thromb. Diathes. Haemorrh., 26, 362 (1971).

    CAS  Article  Google Scholar 

  2. Bowie, E. J. W., Owen, C. A., Thompson, J. H., and Didisheim, P., Amer. J. Clin. Path., 52, 69 (1969).

    CAS  Article  Google Scholar 

  3. Meyer, D., Lavergne, J.-M., Larrieu, M.-J., and Josso, F., Thrombosis Res., 1, 183 (1972).

    CAS  Article  Google Scholar 

  4. Laurell, C. B., Analyt. Biochem., 15, 45 (1966).

    CAS  Article  Google Scholar 

  5. Michal, F., and Born, G. V. R., Nature, 231, 220 (1971).

    CAS  Google Scholar 

  6. Born, G. V. R., Nature, 194, 927 (1962).

    ADS  CAS  Article  Google Scholar 

  7. Newman, J., Johnson, A. J., Karpatkin, M. H., and Puszkin, S., Brit. J. Haematol, 21, 1 (1971).

    CAS  Article  Google Scholar 

  8. Bouma, B. N., Wiegerinck, Y., Sixma, J. J., van Mourik, J. A., and Mochtar, I. A., Nature New Biology, 236, 104 (1972).

    CAS  Article  Google Scholar 

  9. Laurell, C. B., Anal. Biochem., 10, 358 (1965).

    CAS  Article  Google Scholar 

  10. Meyer, D., and Larrieu, M.-J., J. Clin. Path., 23, 228 (1970).

    CAS  Article  Google Scholar 

  11. Zimmerman, T. S., Ratnoff, O. D., and Powell, A. E., J. Clin. Invest., 50, 244 (1971).

    CAS  Article  Google Scholar 

  12. Stites, D. P., Hershgold, E. J., Perlman, J. D., and Fudenberg, H. H., Science, 171, 196 (1971).

    ADS  CAS  Article  Google Scholar 

  13. Hoyer, L. W., Blood, 39, 481 (1972).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

MEYER, D., JENKINS, C., DREYFUS, M. et al. Experimental Model for von Willebrand's Disease. Nature 243, 293–294 (1973).

Download citation

  • Received:

  • Issue Date:

  • DOI:

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing