Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Double Helix at Atomic Resolution

Abstract

The sodium salt of the dinucleoside phosphate adenosyl-3′,5′-uridine phosphate crystallizes in the form of a right handed antiparallel double helix with Watson-Crick hydrogen bonding between uracil and adenine. A sodium ion is located in the minor groove of the helix complexed to both uracil rings.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Watson, J. D., and Crick, F. H. C., Nature, 171, 737 (1953).

    ADS  CAS  Article  Google Scholar 

  2. Fuller, W., Wilkins, M. H. F., Wilson, H. R., and Hamilton, L. D., J. Mol. Biol., 12, 60 (1965).

    CAS  Article  Google Scholar 

  3. Langridge, R., and Gomatos, P. J., Science, 141, 694 (1963).

    ADS  CAS  Article  Google Scholar 

  4. Tomita, K., and Richa, A., Nature, 201, 1160 (1964).

    ADS  CAS  Article  Google Scholar 

  5. Arnott, S., Dover, S. D., and Wonacott, A. J., Acta Cryst., B, 25, 2192 (1969).

    CAS  Article  Google Scholar 

  6. Rich, A., Davies, D. R., Crick, F. H. C., and Watson, J. D., J. Mol. Biol., 3, 71 (1961).

    CAS  Article  Google Scholar 

  7. Arnott, S., Hukins, D. W. L., and Dover, S. D., Biochem. Biophys. Res. Comm., 48, 1392 (1972).

    CAS  Article  Google Scholar 

  8. Arnott, S., and Hukins, D. W. L., Biochem. Biophys. Res. Comm., 47, 1504 (1972).

    CAS  Article  Google Scholar 

  9. Donahue, J., Science, 165, 1091 (1969).

    ADS  Article  Google Scholar 

  10. Wilkins, M. H. F., Arnott, S., Marvin, D. A., and Hamilton, L. D., Science, 167, 1693 (1970).

    ADS  CAS  Article  Google Scholar 

  11. Crick, F. H. C., Science, 167, 1694 (1970).

    CAS  Article  Google Scholar 

  12. Arnott, S., Science, 167, 1694 (1970).

    CAS  Article  Google Scholar 

  13. Donahue, J., Science, 167, 1700 (1970).

    Article  Google Scholar 

  14. Seeman, N. C., Sussman, J. L., Berman, H. M., and Kim, S.-H., Nature New Biology, 233, 90 (1971).

    CAS  Article  Google Scholar 

  15. Corfield, P. W. R., and Rosenstein, R. D., Trans. Amer. Cryst. Assoc., 2, 17 (1966).

    CAS  Google Scholar 

  16. Seeman, N. C., thesis, Univ. Pittsburgh (1970).

  17. Karle, J., and Hauptman, H., Acta Cryst., 17, 392 (1964).

    CAS  Article  Google Scholar 

  18. Voet, D., and Rich, A., Prog. Nucl. Acid. Res. Mol. Biol., 10, 183 (1970).

    CAS  Article  Google Scholar 

  19. Sunderalingam, M., Biopolymers, 7, 821 (1969).

    Article  Google Scholar 

  20. Donahue, J., and Trueblood, K. N., J. Mol. Biol., 2, 363 (1960).

    Article  Google Scholar 

  21. Sussman, J. L., Seeman, N. C., Kim, S.-H., and Berman, H. M., J. Mol. Biol., 66, 403 (1972).

    CAS  Article  Google Scholar 

  22. Rubin, J., Brennan, T., and Sundaralingam, M., Biochemistry, 11, 3112 (1972).

    CAS  Article  Google Scholar 

  23. Kim, S.-H., Berman, H. M., Seeman, N. C., and Newton, M. D., Acta Cryst. (in the press).

  24. Kim, S. H., Quigley, G. J., Suddath, F. L., MacPherson, A., Sneden, D., Kim, J. J. P., Weinzierl, J., and Rich, A., Science, 179, 285 (1973).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ROSENBERG, J., SEEMAN, N., KIM, J. et al. Double Helix at Atomic Resolution. Nature 243, 150–154 (1973). https://doi.org/10.1038/243150a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/243150a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing