Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mortality Rate in Male and Female Guinea-pigs on a Scorbutogenic Diet

Abstract

Odumosu and Wilson1 have reported the unexpected observation that a significant proportion of female guinea-pigs were able to survive for an unusually long period (in some cases perhaps indefinitely) on a diet free of ascorbic acid, implying that these animals could synthesize the vitamin endogenously. The literature on experimental scurvy in guinea-pigs contains, as far as we are aware, no past studies on the mortality of guinea-pigs deprived of an exogenous source of ascorbic acid in relation to sex. In experiments the animals were killed before they reached the point where death from scurvy might be expected, and the sex of animals was either not stated or male only. Nevertheless it has been assumed that both male and female guinea-pigs require an exogenous supply of ascorbic acid and that administration of an ascorbic acid-free diet would lead to the death of all animals, irrespective of sex, within 3–4 weeks. In view of the importance of the observation of Odumosu and Wilson1 in respect of the nature of the lesion in ascorbic acid metabolism in guinea-pigs and as it might reflect on the requirements of humans for an exogenous supply of the vitamin, we felt it necessary to verify their finding.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Odumosu, A., and Wilson, C. W. M., Brit. J. Pharmacol., 42, 637P (1971).

    CAS  Google Scholar 

  2. Reid, M. E., and Briggs, G. M., J. Nutr., 51, 341 (1953).

    Article  CAS  Google Scholar 

  3. Reid, M. E., in The Vitamins (edit. by Sebrell, W. H., and Harris, R. S.), 1, 269 (Academic Press, New York, 1954).

    Book  Google Scholar 

  4. Jones, P. R., Hurley, R. J., and Hughes, R. E., Nature, 242, 521 (1973).

    ADS  Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

BARNES, M., CONSTABLE, B., IMPEY, S. et al. Mortality Rate in Male and Female Guinea-pigs on a Scorbutogenic Diet. Nature 242, 522–523 (1973). https://doi.org/10.1038/242522a0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/242522a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing