Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Linkage Analysis in Man by Somatic Cell Genetics

Nature volume 242, pages 165–169 (1973)Cite this article

Abstract

Techniques for the study of somatic cell genetics, and particularly those involving the expression of enzyme markers in hybrid cells, have already made possible a large number of gene-chromosome assignments. Genetic and family studies, as well as cellular studies on recombination and gene transfer, promise more and quicker results in the future.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Barski, G., Sorieul, S., and Cornefert, F., CR Acad. Sci., 251, 1825 (1960).

    CAS  Google Scholar 

  2. Ephrussi, B., and Weiss, M. C., Proc. US Nat. Acad. Sci., 53, 1040 (1965).

    Article  ADS  CAS  Google Scholar 

  3. Ephrussi, B., and Weiss, M. C., Develop. Biol. Suppl. I., 136 (1967).

  4. Weiss, M. C., and Green, H., Proc. US Nat. Acad. Sci., 58, 1104 (1967).

    Article  ADS  CAS  Google Scholar 

  5. Harris, H., and Watkins, J. F., Nature, 205, 640 (1965).

    Article  ADS  CAS  Google Scholar 

  6. Okada, Y., and Murayama, F., Exp. Cell Res., 52, 34 (1968).

    Article  CAS  Google Scholar 

  7. Lucy, J. A., Nature, 227, 815 (1970).

    Article  ADS  CAS  Google Scholar 

  8. Littlefield, J. W., Science, 145, 709 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Kusano, T., Long, C., and Green, H., Proc. US Nat. Acad. Sci., 68, 82 (1971).

    Article  ADS  CAS  Google Scholar 

  10. Puck, T. T., and Kao, F. A., Proc. US Nat. Acad. Sci., 58, 1227 (1967).

    Article  ADS  CAS  Google Scholar 

  11. Kao, F. T., and Puck, T. T., Nature, 228, 329 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Thompson, L. H., Mankovitz R., Baker, R. M., Tell, J. E., Seminovitch, L., and Whitmore, G. F., Proc. US Nat. Acad. Sci., 66, 377 (1970).

    Article  ADS  CAS  Google Scholar 

  13. Davidson, R. L., and Ephrussi, B., Nature, 205, 1170 (1965).

    Article  ADS  Google Scholar 

  14. Santachiara, A. S., Nabholz, M., Miggiano, V., Darlington, A. J., and Bodmer, W., Nature, 227, 248 (1970).

    Article  ADS  CAS  Google Scholar 

  15. Jami, J., Grandchamp, S., and Ephrussi, B., CR Acad. Sci., 272, 323 (1971).

    CAS  Google Scholar 

  16. Ruddle, F. H., Adv. Hum. Genet., 3, 173 (1972).

    Article  CAS  Google Scholar 

  17. Nabholz, M., Miggiano, V., and Bodmer, W., Nature, 223, 358 (1969).

    Article  ADS  CAS  Google Scholar 

  18. Ruddle, F. H., and Nichols, E., In Vitro, 7, 120 (1971).

    Article  CAS  Google Scholar 

  19. Davidson, R. L., In Vitro, 6, 411 (1971).

    Article  CAS  Google Scholar 

  20. Ricciuti, F., thesis, Yale Univ. (1972).

  21. Caspersson, T., Zech, L., Johansson, C., and Modest, E., Chromosoma, 30, 215 (1970).

    Article  CAS  Google Scholar 

  22. Miller, O. J., Miller, D. A., Kouri, R. E., Alderdice, P. W., Dev, V. G., Grewal, M. S., and Hutton, J. J., Proc. US Nat. Acad. Sci., 68, 1530 (1971).

    Article  ADS  CAS  Google Scholar 

  23. Sumner, A. T., Evans, H. J., and Buckland, R. A., Nature New Biology, 232, 31 (1971).

    Article  CAS  Google Scholar 

  24. Pardue, M. L., and Gall, J. G., Science, 168, 1356 (1970).

    Article  ADS  CAS  Google Scholar 

  25. Arrighi, F. E., and Hsu, T. C., Cytogenetics, 10, 81 (1971).

    Article  CAS  Google Scholar 

  26. Chen, T. R., and Ruddle, F. H., Chromosoma, 34, 51 (1971).

    Article  CAS  Google Scholar 

  27. Ruddle, F. H., Symp. Intern. Soc. Cell Biol., 9, 233 (1970).

    Google Scholar 

  28. Bobrow, M., Madan, K., and Pearson, P. L., Nature New Biology, 238, 122 (1972).

    Article  CAS  Google Scholar 

  29. Boone, C. M., Chen, T. R., and Ruddle, F. H., Proc. US Nat. Acad. Sci., 69, 510 (1972).

    Article  ADS  CAS  Google Scholar 

  30. Van Cong, N., Billerdon, C., Picard, J. Y., Feingold, J., and Frizal, J., CR Acad. Sci., 272, 485 (1971).

    Google Scholar 

  31. Ruddle, F. H., Ricciuti, F., McMorris, F. A., Tischfield, J., Creagan, R., Darlington, G., and Chen, T. R., Science, 176, 1429 (1972).

    Article  ADS  CAS  Google Scholar 

  32. Westerveld, A., and Meera Khan, P., Nature, 236, 30 (1972).

    Article  ADS  CAS  Google Scholar 

  33. Brewer, G. J., Amer. J. Hum. Genet., 19, 674 (1967).

    CAS  Google Scholar 

  34. Hamerton, J., Cytogenetics (in the press).

  35. Kao, F. T., and Puck, T. T., Proc. US Nat. Acad. Sci., 69, 3273 (1972).

    Article  ADS  CAS  Google Scholar 

  36. Chen, T. R., McMorris, F. A., Creagan, R., Ricciuti, F., Tischfield, J., and Ruddle, F. H., Amer. J. Hum. Genet. (in the press).

  37. McMorris, F. A., Chen, T. R., Ricciuti, F., Tischfield, J., Creagan, R., and Ruddle, F. H., Science (in the press).

  38. Shows, T. B., Abstr., Amer. J. Hum. Genet., 24, 13a (1972).

    Google Scholar 

  39. Shows, T. B., Proc. US Nat. Acad. Sci., 69, 348 (1972).

    Article  ADS  CAS  Google Scholar 

  40. van Someren, H., Meera Khan, P., Westerveld, A., and Bootsma, R., Nature New Biology, 240, 221 (1972).

    Article  CAS  Google Scholar 

  41. Puck, T. T., Wuthier, P., Jones, C., and Kao, F., Proc. US Nat. Acad. Sci., 68, 3102 (1971).

    Article  ADS  CAS  Google Scholar 

  42. Ruddle, F. H., and Chen, T. R., in Genetics and the Skin, Twentyfirst Ann. Symp.: Biol. Skin (1972).

    Google Scholar 

  43. Ruddle, F. H., Chapman, V. M., Chen, T. R., and Kleke, R. J., Nature, 227, 251 (1970).

    Article  ADS  CAS  Google Scholar 

  44. Shows, T., Biochem. Genet., 7, 193 (1972).

    Article  CAS  Google Scholar 

  45. Jones, C., Wuthier, P., Kao, F., and Puck, T. T., J. Cell Physiol. (in the press).

  46. Ruddle, F. H., in The Use of Long Term Lymphocytes in the Study of Genetic Diseases (edit. by Bergsma, D., Smith, G., and Bloom, A.) (National Foundation, in the press).

  47. Edwards, Y. H., Hopkinson, D. A., and Harris, H., Ann. Human Genetics, 34, 395 (1971).

    Article  CAS  Google Scholar 

  48. Robson, E. B., Polani, P. E., Dart, S. J., Jacobs, P. A., and Renwick, J. H., Nature, 223, 1163 (1969).

    Article  ADS  CAS  Google Scholar 

  49. Green, H., in Heterospecific Genome Interaction Wiston Inst. Lymp. Monograph, No. 9, 51 (1969).

    Google Scholar 

  50. Migeon, B. R., and Miller, O. S., Science, 162, 1005 (1968).

    Article  ADS  CAS  Google Scholar 

  51. Boone, C. M., and Ruddle, F. H., Biochem. Genet., 3, 119 (1969).

    Article  CAS  Google Scholar 

  52. Miller, O. J., Alderdice, P. W., Miller, D. A., Breg, W. R., and Migeon, B. R., Science, 173, 244 (1971).

    Article  ADS  CAS  Google Scholar 

  53. Ruddle, F. H., and Chen, T. R., in Perspectives in Cytogenetics (edit. by Wright, S. W., and Crandall, B. F.) (Charles C. Thomas, Illinois, 1971).

    Google Scholar 

  54. Kit, S., Nakajima, K., and Dubbs, D. R., J. Virol., 5, 446 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  55. McDougall, J. K., J. Gen. Virol., 12, 43 (1971).

    Article  CAS  Google Scholar 

  56. Edwards, J. E., Allen, F. H., Glenn, K. P., Lamm, L. U., and Robson, E. B., Histocompatibility Testing (in the press).

  57. Tan, Y. H., Tischfield, J., and Ruddle, F. H., J. Exp. Med. (in the press).

  58. Cassingena, R., Chany, C., Vignal, M., Suarez, H., and Estrade, S., Proc. US Nat. Acad. Sci., 68, 580 (1971).

    Article  ADS  CAS  Google Scholar 

  59. McKusick, V. A., Mendelian Inheritance in Man, third ed. (Johns Hopkins Press, Baltimore, 1971).

    Google Scholar 

  60. Meera Khan, P., Westerveld, A., Grzeschik, K. H., Deys, B. F., Garson, O. M., and Siniscalco, M., Amer. J. Hum. Genet., 23, 614 (1971).

    CAS  PubMed  Google Scholar 

  61. Ruddle, F. H., Chapman, V. M., Ricciuti, F., Murnane, M., Klebe, R., and Meera Khan, P., Nature, 232, 69 (1971).

    CAS  Google Scholar 

  62. Grzeschik, K. H., Romeo, G., Grzeschik, A. M., Banhof, S., Siniscalco, M., van Someren, H., Meera Khan, P., Westerveld, A., and Bootsma, R., Nature (in the press).

  63. Grzeschik, K. H., Alderdice, P. W., Grzeschik, A., Opitz, J. M., Miller, O. J., and Siniscalco, M., Proc. US Nat. Acad. Sci., 69, 69 (1972).

    Article  ADS  CAS  Google Scholar 

  64. Comings, D. E., Nature, 238, 455 (1972).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kline Biology Tower, Yale University, New Haven, Connecticut, 06520

    FRANK H. RUDDLE

Authors
  1. FRANK H. RUDDLE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RUDDLE, F. Linkage Analysis in Man by Somatic Cell Genetics. Nature 242, 165–169 (1973). https://doi.org/10.1038/242165a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/242165a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing