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UK 786 Possible Species-Specific Toxicant for Norway Rats

Abstract

UK 7861 (5-(N-piperidino)-10,11-dihydro-5H-dibenzo (a.d.)-cycloheptene (Dr J. Morrison, Pfizer Ltd.)) is a compound whose acute oral LD50 has been reported to be 6.6 mg kg−1 in male albino rats and 1,160 mg in male albino mice2. These data suggested that UK 786 might be a highly specific toxicant for rats, and we conducted the following series of tests with thirteen species of birds and mammals to investigate this.

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References

  1. British Patent, No. 1,028,233 (1966).

  2. Morrison, J. K., Quinton, R. M., and Reinert, H., in Modern Trends in Toxicology (edit. by Boyland, E., and Goulding, R.), 1, 6 (Appleton-Century-Crofts, New York, 1968).

    Google Scholar 

  3. Litchfield, J. T., jun., and Wilcoxon, F., J. Pharmacol. Exp. Ther., 96, 99 (1949).

    CAS  PubMed  Google Scholar 

  4. Thompson, W. R., Bact. Rev., 11, 115 (1947).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Thompson, W. R., and Weil, C. S., Biometrics, 8, 51 (1952).

    Article  Google Scholar 

  6. Boyle, C. M., Nature, 188, 517 (1960).

    Article  ADS  Google Scholar 

  7. Jackson, W. B., and Kaukeinen, D., Science, 176, 1343 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Roszkowski, A. P., Poos, G. I., and Mohrbacher, R. J., Science, 144, 412 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

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SAVARIE, P., MATSCHKE, G., SCHAFER, E. et al. UK 786 Possible Species-Specific Toxicant for Norway Rats. Nature 241, 551–552 (1973). https://doi.org/10.1038/241551a0

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