Abstract
ALTHOUGH the parasitology of malaria has been extensively studied1, biochemical aspects of the relationships between the intra-erythrocytic parasite and its host erythrocyte are poorly understood. The main source of metabolic energy for the erythrocytic stages of the parasite is the breakdown of glucose with formation of lactic acid2–6, which it may carry out independently of the red cell2. Catabolism of glucose by metabolic pathways other than glycolysis may occur, although the overall pattern of glucose breakdown appears to vary with the species of malaria parasite7. The ability of the parasite, as distinct from the erythrocyte, to carry out the reactions of the pentose phosphate pathway is unresolved8–11,19.
Similar content being viewed by others
Article PDF
References
Garnham, P. C. C., in Malaria Parasites and other Haemosporidia, 1144 (Blackwell, London, 1966).
Speck, J. F., and Evans, jun., E. A., J. Biol. Chem., 159, 71 (1945).
McKee, R. W., in Biochemistry and Physiology of Protozoa (edit. by Lwoflf, A.), 1, 251 (Academic Press, NY, 1951).
Moulder, J. W., in The Biochemistry of Intracellular Parasites (University of Illinois Press, Chicago, 1962).
Bryant, C., Voller, A., and Smith, M. J. H., Am. J. Trop. Med. Hyg., 13, 515 (1964).
Scheibel, L. W., and Pflaum, W. K., Comp. Biochem. Physiol., 37, 243 (1970).
Peters, W., Trop. Dis. Bull., 66, 1 (1969).
Herman, Y. F., Ward, R. A., and Herman, R. H., Am. J. Trop. Med. Hyg., 15, 276 (1966).
Bowman, I. B. R., Grant, P. T., Kermack, O., and Ogston, D., Biochem. J., 78, 474 (1961).
Langer, jun., B. W., Phisphumvidhi, P., and Friedlander, V.., Ex. Parasitol, 20, 68 (1967).
Fletcher, A., and Maegraith, B. G., Nature, 196, 1316 (1962).
Hutton, J. J., Anal. Biochem., 45, 577 (1972).
Williamson, J., and Cover, B., Trans. Roy. Soc. Trop. Med. Hyg., 60, 425 (1966).
Brown, I. N., Brown, K. N., and Hills, L. A., Trans. Roy. Soc. Trop. Med. Hyg., 60, 2 (1966).
Rose, I. A., and Warms, J. V. B., J. Biol. Chem., 241, 4848 (1966).
Katz, J., and Wood, H. G., J. Biol. Chem., 235, 2165 (1960).
Katz, J., and Wood, H. G., J. Biol. Chem., 238, 517 (1963).
Axelrod, B., in Metabolic Pathways (third edit.) (edit. by Greenberg, D. M.), 271 (Academic Press, NY, 1971).
Barnes, M. G., and Polet, H., J. Lab. Clin. Med., 74, 1 (1969).
Brin, M., and Yonemoto, R. H., J. Biol. Chem., 230, 307 (1958).
Green, D. E., Murer, E., Hulton, H. O., Richardson, S. H., Salmon, B., Brierly, G. P., and Baum, H., Arch. Biochem. Biophys., 112, 635 (1965).
Emmelot, P., and Bos, C. J., Biochim. Biophys. Acta, 121, 434 (1966).
Hulton, H. O., and Westort, C., Arch. Biochem. Biophys., 117, 523 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHAKESPEARE, P., TRIGG, P. Glucose Catabolism by the Simian Malaria Parasite Plasmodium knowlesi. Nature 241, 538–540 (1973). https://doi.org/10.1038/241538a0
Issue Date:
DOI: https://doi.org/10.1038/241538a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.