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Biological Sciences: Papova Virus in Urine after Renal Transplantation


THE excretion of viruses of the papova type in urine following renal transplantation has been described only in a single case1. Excretion of herpes viruses is more common, and a high incidence of warts in transplant patients has also been reported2. A papova-like virus has been found in brain material of patients with progressive multifocal leuco-encephalopathy (PML) and such viruses have been cultured from cases of PML complicating Hodgkin's disease3,4. Immuno-suppressive therapy activates latent viruses5 and is associated with a high incidence of malignant tumours6. We report here the excretion in urine of a papova-like virus by approximately 45% of patients in a renal transplant unit.

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  1. 1

    Gardner, Sylvia D., Field, Anne M., Coleman, Dulcie V., and Hulme, B., Lancet, i, 1253 (1971).

  2. 2

    Spencer, E. S., and Anderson, H. K., Brit. Med. J., iii, 251 (1970).

  3. 3

    Padgett, B. L., Walker, D. L., ZuRhein, Gabriele M., and Eckroade, R. J., Lancet, i, 1257 (1971).

  4. 4

    Weiner, L. P., Herndon, R. M., Narayan, O., Johnson, R. T., Shah, K., Rubinstein, L. J., Prezios, T. J., and Conley, F. K., New Eng. J. Med., 286, 385 (1972).

  5. 5

    Schwarz, R. S., Lancet, i, 1266 (1972).

  6. 6

    Penn, I., Halgrimson, C. G., and Starzl, T. E., Transpl. Proc., 3, 340 (1971).

  7. 7

    Lecatsas, G., and Malucci, L., Arch. Ges. Virusforsch., 37, 340 (1972).

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