Figure 2: Two ways that a lymphocyte can kill a target cell. | Nature

Figure 2: Two ways that a lymphocyte can kill a target cell.

From: Cell suicide for beginners

Figure 2

In both cases procaspases are activated in the target cell, leading to apoptosis. a, The lymphocyte secretes proteins onto the target cell surface: the perforin protein assembles into channels that enable the granzyme B protein to enter the target cell and activate procaspases. b, Fas ligand on the lymphocyte surface binds to the Fas protein on the target cell, causing the Fas molecules to form clusters. An adaptor protein then binds to the clustered Fas molecules and recruits inactive procaspase-8 molecules, which then activate one another to initiate the caspase cascade.

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