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Differential expression of Sonic hedgehog and Gli1 in hematological malignancies

Leukemia volume 22, pages 226–228 (2008)Cite this article

Hedgehog (Hh) proteins are a family of intercellular signaling molecules. They are originally identified as a polarization gene required for embryonic patterning in Drosophila.1 Sonic hedgehog homolog (Shh) gene is studied more thoroughly among three mammalian homologs. Shh regulates a wide range of developmental processes in tissues, including skin, nervous system, foregut, lung, limbs, pituitary gland and pancreas.2 In terms of tumorigenesis, it has been described that Ptc, a gene encoding a protein as the receptor of Shh, behaves as a tumor suppressor gene, and Smo as well as its downstream signaling Gli genes are oncogenic.3 Medulloblastoma and basal cell carcinoma are malignancies most associated with the hedgehog pathway. In addition, Shh pathway has also been reported to play an important role in the malignant potential of small cell lung cancer and cancers of stomach, esophagus, pancreas, biliary tract, prostate gland and human intestinal stromal tumors.3

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Acknowledgements

This work was supported in part by a grant from China Medical University (Taichung, Taiwan) Research Grant DMR-96-107.

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

    L-Y Bai & C-F Chiu

  2. Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    L-Y Bai, C-F Chiu & M-C Kao

  3. Department of Medical Technology, College of Health Care, China Medical University, Taichung, Taiwan

    C-W Lin

  4. Department of Surgery, China Medical University Hospital, Taichung, Taiwan

    N-Y Hsu

  5. Department of Medical Research, Stem Cell Research Laboratory, China Medical University Hospital, Taichung, Taiwan

    C-L Lin & W-J Lo

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  1. L-Y Bai
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Correspondence to M-C Kao.

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Bai, LY., Chiu, CF., Lin, CW. et al. Differential expression of Sonic hedgehog and Gli1 in hematological malignancies. Leukemia 22, 226–228 (2008). https://doi.org/10.1038/sj.leu.2404978

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