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Acute Leukemias

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia

Leukemia volume 21, pages 2406–2410 (2007)Cite this article

Abstract

Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.

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Acknowledgements

We thank Lone Svendstrup for expert technical assistance. This study was supported by grants from The Danish Medical Research Council to NB, CUN was supported by a grant from H:S, Copenhagen University Hospital, ER was supported by grants from the Novo Nordisk Foundation and the HS Research Council.

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Authors and Affiliations

  1. Department of Hematology, Rigshospitalet, Copenhagen, Denmark

    C U Niemann, L Kjeldsen & N Borregaard

  2. Department of Pathology, Rigshospitalet, Copenhagen, Denmark

    E Ralfkiaer & M K Jensen

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  1. C U Niemann
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  2. L Kjeldsen
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  3. E Ralfkiaer
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  4. M K Jensen
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  5. N Borregaard
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Correspondence to C U Niemann.

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Niemann, C., Kjeldsen, L., Ralfkiaer, E. et al. Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia. Leukemia 21, 2406–2410 (2007). https://doi.org/10.1038/sj.leu.2404975

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