Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Induction of folate receptor type β in a bone marrow engraftment model of acute myelogenous leukemia

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1
Figure 2
Figure 3

References

  1. Elnakat H, Ratnam M . Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. In: Low PS, Anthony AC (eds). Advanced Drug Delivery Reviews, vol. 56. Elsevier: Amsterdam, The Netherlands, 2004, pp 1067–1084.

    Google Scholar 

  2. Paulos CM, ZTurk MJ, Breur GJ, Low PS . Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. In: Low PS, Anthony AC (eds). Advanced Drug Delivery Reviews, vol. 56. Elsevier: Amsterdam, The Netherlands, 2004, pp 1205–1218.

    Google Scholar 

  3. Ross JF, Wang H, Mathew P, Wu M, Booth R, Ratnam M . Folate receptor type β is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia. Cancer 1999; 85: 348–357.

    Article  CAS  PubMed  Google Scholar 

  4. Nakashima-Matsushita N, Homma T, Yu S, Matsuda T, Sunahara N, Nakemura T et al. Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from rheumatoid arthritis patients. Arthritis Rheum 1999; 42: 1609–1616.

    Article  CAS  PubMed  Google Scholar 

  5. Pan XQ, Zheng X, Shi G, Wang H, Ratnam M, Lee RJ . Strategy for the treatment of acute myelogenous leukemia based on folate receptor β-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid. Blood 2002; 100: 594–602.

    Article  CAS  PubMed  Google Scholar 

  6. Wang H, Zheng X, Behm FG, Ratnam M . Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia. Blood 2000; 96: 3529–3536.

    CAS  PubMed  Google Scholar 

  7. Hao H, Qi H, Ratnam M . Modulation of folate receptor type β gene by coordinate interactions of retinoic acid receptors at activator Sp1 and repressor AP1 sites. Blood 2003; 101: 4551–4560.

    Article  CAS  PubMed  Google Scholar 

  8. Qi H, Ratnam M . Synergistic induction of folate receptor β by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective antifolate cytotoxicity. Cancer Res 2006; 66: 5875–5882.

    Article  CAS  PubMed  Google Scholar 

  9. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Canceres-Cortes J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645–648.

    Article  CAS  PubMed  Google Scholar 

  10. Sutherland HJ, Blair A, Zapf RW . Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 1996; 87: 4754–4761.

    CAS  PubMed  Google Scholar 

  11. Bonnet D, Dick JE . Human acute myeloid leukemia is organized as a hierarchy originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730–737.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by NIH RO1 Grant CA080183 to MR and Grant CA095673 to RJL. MR also received support from a Harold and Helen McMaster endowment.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M Ratnam.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Blaser, B., Gonit, M., Qi, H. et al. Induction of folate receptor type β in a bone marrow engraftment model of acute myelogenous leukemia. Leukemia 21, 2233–2235 (2007). https://doi.org/10.1038/sj.leu.2404786

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404786

This article is cited by

Search

Quick links