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Molecular detection of GNNK− and GNNK+ c-kit isoforms: a new tool for risk stratification in adult acute myeloid leukaemia

Leukemia volume 21, pages 2056–2058 (2007)Cite this article

Acute myeloid leukaemia (AML) is a molecularly, morphologically and phenotypically heterogeneous disease. Multiple recurrent chromosome translocations and gene mutations have been identified, and these alterations have been correlated to biological and clinical features of disease, resulting in delineation of prognostically distinct categories of AML.

Acute myeloid leukaemia would result from several classes of mutations: a class I mutation, which confers a proliferative signal (for example, a receptor tyrosine kinase (RTK)), and a class II mutation, which impairs haematopoietic differentiation, such as the core binding factor fusion genes. Finally, RTK class III mutations have been also linked to other haematological malignancies.

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Authors and Affiliations

  1. Department of Oncology, Transplant and Advances in Medicine, Section of Haematology, University of Pisa, Pisa, Italy

    F Guerrini, S Galimberti, E Ciabatti, S Brizzi, R Testi, A Pollastrini & M Petrini

  2. Institute of Haematology, University of Perugia, Perugia, Italy

    B Falini

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  1. F Guerrini
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  2. S Galimberti
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Correspondence to S Galimberti.

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Guerrini, F., Galimberti, S., Ciabatti, E. et al. Molecular detection of GNNK− and GNNK+ c-kit isoforms: a new tool for risk stratification in adult acute myeloid leukaemia. Leukemia 21, 2056–2058 (2007). https://doi.org/10.1038/sj.leu.2404726

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