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Class I HDAC SNP analysis in healthy donors compared to AML patients

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References

  1. Gozzini A, Santini V . Butyrates and decitabine cooperate to induce histone acetylation and granulocytic maturation of t(8;21) acute myeloid leukemia blasts. Ann Hematol 2005; 84 (Suppl 13): 54–60.

    Article  CAS  PubMed  Google Scholar 

  2. Cress WD, Seto E . Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 2000; 184: 1–16.

    Article  CAS  PubMed  Google Scholar 

  3. Lin RJ, Nagy L, Inoue S, Shao W, Miller Jr WH, Evans RM . Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 1998; 391: 811–814.

    Article  CAS  PubMed  Google Scholar 

  4. Mahlknecht U, Hoelzer D . Histone acetylation modifiers in the pathogenesis of malignant disease. Mol Med 2000; 6: 623–644.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Melnick A, Licht JD . Histone deacetylases as therapeutic targets in hematologic malignancies. Curr Opin Hematol 2002; 9: 322–332.

    Article  PubMed  Google Scholar 

  6. Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 2001; 21: 6470–6483.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Durst KL, Lutterbach B, Kummalue T, Friedman AD, Hiebert SW . The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain. Mol Cell Biol 2003; 23: 607–619.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM . ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA 1998; 95: 10860–10865.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Le Beau MM, Albain KS, Larson RA, Vardiman JW, Davis EM, Blough RR et al. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 1986; 4: 325–345.

    Article  CAS  PubMed  Google Scholar 

  10. Rowley JD, Golomb HM, Vardiman JW . Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood 1981; 58: 759–767.

    CAS  PubMed  Google Scholar 

  11. Mahlknecht U, Bucala R, Hoelzer D, Verdin E . High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. Cytogenet Cell Genet 1999; 86: 237–239.

    Article  CAS  PubMed  Google Scholar 

  12. Collins FS, Brooks LD, Chakravarti A . A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 1998; 8: 1229–1231.

    Article  CAS  PubMed  Google Scholar 

  13. Smigielski EM, Sirotkin K, Ward M, Sherry ST . dbSNP: a database of single nucleotide polymorphisms. Nucleic Acids Res 2000; 28: 352–355.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. The International HapMap Project. Nature 2003; 426: 789–796.

  15. De La Vega FM, Dailey D, Ziegle J, Williams J, Madden D, Gilbert DA . New generation pharmacogenomic tools: a SNP linkage disequilibrium Map, validated SNP assay resource, and high-throughput instrumentation system for large-scale genetic studies. Biotechniques 2002; 32 (Suppl 48-50): 52–54.

    Google Scholar 

  16. Schaich M, Ritter M, Illmer T, Lisske P, Thiede C, Schakel U et al. Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia. Br J Haematol 2001; 112: 300–307.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Mr Markus Zorn and Mr Robin Veit, University of Heidelberg, central laboratory, for primary cells. The contribution of all physicians and patients in the AML96 treatment trial of the DSIL (Deutsche Studieninitiative Leukämie) is highly appreciated. This work was supported by Grants from the Deutsche José Carreras Leukämie-Stiftung e. V (DJCLS R 05/11), the Deutsche Forschungsgemeinschaft (MA 2057/2-4) and the Dietmar Hopp Foundation (Heidelberg) to UM.

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Correspondence to U Mahlknecht.

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Dransfeld, CL., Schaich, M., Ho, A. et al. Class I HDAC SNP analysis in healthy donors compared to AML patients. Leukemia 21, 1587–1590 (2007). https://doi.org/10.1038/sj.leu.2404673

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