Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1
Figure 2

References

  1. Sirohi B, Powles R . Multiple myeloma. Lancet 2004; 363: 875–887.

    Article  Google Scholar 

  2. Zipori D, Duksin D, Tamir M, Argaman A, Toledo J, Malik Z . Cultured mouse marrow stromal cell lines. II. Distinct subtypes differing in morphology, collagen types, myelopoietic factors, and leukemic cell growth modulating activities. J Cell Physiol 1985; 122: 81–90.

    Article  CAS  Google Scholar 

  3. Belaid Z, Hubint F, Humblet C, Boniver J, Nusgens B, Defresne MP . Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells. Haematologica 2005; 90: 400–401.

    CAS  PubMed  Google Scholar 

  4. Vanderkerken K, Asosingh K, Willems A, De Raeve H, Couck P, Gorus F et al. The 5T2MM murine model of multiple myeloma: maintenance and analysis. Methods Mol Med 2005; 113: 191–205.

    PubMed  Google Scholar 

  5. Kumar S, Greipp PR, Haug J, Kline M, Chng WJ, Blood E et al. Gene expression profiling of myeloma cells at diagnosis can predict response to therapy with thalidomide and dexamethasone combination. ASH Annual Meeting Abstracts 2005; 106: 508.

    Google Scholar 

  6. Vanderkerken K, De Greef C, Asosingh K, Arteta B, De Veerman M, Vande Broek I et al. Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse. Br J Cancer 2000; 82: 953–959.

    Article  CAS  Google Scholar 

  7. Alexandrakis MG, Passam FH, Sfiridaki A, Pappa CA, Moschandrea JA, Kandidakis E et al. Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines. Int J Biol Markers 2004; 19: 52–57.

    Article  CAS  Google Scholar 

  8. Gimble JM, Robinson CE, Wu X, Kelly KA . The function of adipocytes in the bone marrow stroma: an update. Bone 1996; 19: 421–428.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was financially supported by the Onderzoeksraad-VUB, the Fund for Scientific Research-Vlaanderen (FWO-Vlaanderen), the Belgian Federation against Cancer, the Association for International Cancer Research and Willy Gepts Foundation(AZ-VUB). K Vanderkerken is a post-doctoral fellow of FWO-Vlaanderen. We also thank Angelo Willems and Carine Seynaeve for excellent technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K Vanderkerken.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Caers, J., Deleu, S., Belaid, Z. et al. Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. Leukemia 21, 1580–1584 (2007). https://doi.org/10.1038/sj.leu.2404658

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404658

This article is cited by

Search

Quick links