Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Aberrant expression of HLA-DR antigen by bone marrow-derived mesenchymal stromal cells from patients affected by acute lymphoproliferative disorders

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC et al. Clarification of the nomenclature of MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005; 7: 393–395.

    Article  CAS  Google Scholar 

  2. Pittenger M, Mackay A, Beck S, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 2000; 284: 143–147.

    Article  Google Scholar 

  3. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838–3843.

    Article  CAS  Google Scholar 

  4. Saccardi R, Mancardi GL, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P et al. Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood 2005; 105: 2601–2607.

    Article  CAS  Google Scholar 

  5. Aggarwall S, Pittenger MF . Human mesenchymal cells modulate allogenic immune cell response. Blood 2000; 105: 1815–1822.

    Article  Google Scholar 

  6. Bacigalupo A, Valle M, Podesta' M, Pitto A, Zocchi E, De Flora A et al. T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia. Exp Hematol 2005; 33: 819–827.

    Article  CAS  Google Scholar 

  7. Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O . HLA expression and immunological properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003; 31: 890–896.

    Article  CAS  Google Scholar 

  8. Campioni D, Moretti S, Ferrari L, Punturieri M, Castoldi GL, Lanza F . Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment. Haematologica 2006; 91: 364–368.

    PubMed  Google Scholar 

  9. Drenou B, Le Friec G, Bernard M, Pangault C, Grosset JM, Lamy T et al. Major histocompatibility complex abnormalities in non-Hodgkin lymphoma. Br J Haematol 2002; 119: 417–424.

    Article  CAS  Google Scholar 

  10. Kimura H, Kimura M, Tzou SC, Chen YC, Suzuki K, Rose NR et al. Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization. Endocrinology 2005; 146: 1154–1162.

    Article  CAS  Google Scholar 

  11. Prockop SE, Palencia S, Ryan CM, Gordon K, Gray D, Petrie HT . Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex. J Immunol 2002; 169: 4354–4361.

    Article  CAS  Google Scholar 

  12. Ruiz C, Reyes-Botella C, Garcia-martinez O, Montes MJ . Modulation of antigenic phenotype by IL-1b, INF-γ and TGF-β on cultured human decidual stromal cells. Biosci Rep 2004; 24: 55–62.

    Article  CAS  Google Scholar 

  13. Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M . Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 2006; 24: 1409–1410.

    Article  Google Scholar 

  14. Campioni D, Punturieri M, Bardi A, Moretti S, Tammiso E, Lanza F et al. ‘In vitro’ evaluation of bone marrow angiogenesis in myelodysplastic syndromes: a morphological and functional approach. Leuk Res 2004; 28: 9–17.

    Article  Google Scholar 

Download references


This work was supported by AIRC Regional Grant and MIUR (Italy).

Author information

Authors and Affiliations


Corresponding author

Correspondence to F Lanza.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lanza, F., Campioni, D., Moretti, S. et al. Aberrant expression of HLA-DR antigen by bone marrow-derived mesenchymal stromal cells from patients affected by acute lymphoproliferative disorders. Leukemia 21, 378–381 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links