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JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia

Leukemia volume 21, pages 367–369 (2007)Cite this article

Juvenile myelomonocytic leukemia (JMML) is a unique clonal myelodysplastic/myeloproliferative disorder of infancy and early childhood, characterized by an aggressive clinical course and an extremely poor prognosis for patients who cannot receive an allogeneic hematopoietic stem cell transplantation.1, 2 The disease, usually presenting with leukocytosis and monocytosis, anemia, thrombocytopenia, hepatomegaly and marked splenomegaly, is characterized by an uncontrolled proliferation of monocytic lineage cells. Spontaneous growth of monocyte–macrophage colonies in semisolid media cultures in the absence of added growth factors, as well as a striking hypersensitivity of JMML myeloid progenitors to granulocyte–macrophage colony-stimulating factor (GM-CSF), is a distinctive feature of the disease.1

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Acknowledgements

This work was supported in part by grants from Ministero della Salute–IRCCS Policlinico San Matteo (Ricerca Corrente grants 80458 and 80125) to MZ and FL and by a private Italian grant in memory of Sofia Luce Rebuffat, to FL

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Authors and Affiliations

  1. Pediatric Hematology/Oncology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    M Zecca, D Lisini & F Locatelli

  2. Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    G Bergamaschi

  3. Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University of Freiburg, Freiburg, Germany

    C Kratz & C M Niemeyer

  4. Department of Oncology, University Children's Hospital, Zürich, Switzerland

    E Bergsträßer

  5. Medical Genetics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    C Danesino & P De Filippi

  6. Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark

    H Hasle

  7. Pediatric Hematology/Oncology, University of Bologna, Policlinico Sant'Orsola, Bologna, Italy

    A Pession

  8. Pediatric Hematology/Oncology, University of Padova, Padova, Italy

    L Sainati

  9. Pediatric Hematology/Oncology, University Hospital Motol, Prague, Czech Republic

    J Starý

  10. Department of Pediatrics, St Anna Kinderspital, Wien, Austria

    M Trebo

  11. Dutch Childhood Oncology Group, The Hague, ErasmusMC–Sophia Children's Hospital, Rotterdam, The Netherlands

    M van den Heuvel-Eibrink

  12. Department of Pediatric Hematology/Oncology, Wroclaw, Poland

    D Wójcik

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  1. M Zecca
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Zecca, M., Bergamaschi, G., Kratz, C. et al. JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia. Leukemia 21, 367–369 (2007). https://doi.org/10.1038/sj.leu.2404484

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