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Reply to ‘Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation’ by E Wohlfert and Clark RB

Leukemia volume 21, page 175 (2007)Cite this article

Wohlfert EA and Clark RB had interesting comments1 to our article ‘Addition of the CD28 signaling domain to chimeric T cell receptors enhances CTL activation and resistance to T regulatory cells' that was published in Leukemia online on 17 August 2006.2 We agree it is of interest to observe related phenomena in other experimental systems and we welcome this additional validation.

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References

  1. Wohlfert EA, Clark RB . Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation (Letter to the Editor). Leukemia 2006.

  2. Loskog A, Giandomenico V, Rossig C, Pule M, Rooney CM, Dotti G et al. Addition of the CD28 signaling domain to chimeric T cell receptors enhances CTL activation and resistance to T regulatory cells. Leukemia. Advance online publication, 17 August 2006.

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Authors and Affiliations

  1. Clinical Immunoly, Div/Uppsala University, Rudbeck Laboratory, Uppsala, Sweden

    A Loskog

  2. Baylor College of Medicine, Houston, TX, USA

    M K Brenner

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  1. A Loskog
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  2. M K Brenner
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Correspondence to A Loskog.

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Loskog, A., Brenner, M. Reply to ‘Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation’ by E Wohlfert and Clark RB. Leukemia 21, 175 (2007). https://doi.org/10.1038/sj.leu.2404454

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  • DOI: https://doi.org/10.1038/sj.leu.2404454

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