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Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation

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  1. Loskog A, Giandomenico V, Rossig C, Dotti G, Brenner MK . Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia (published online August 17, 2006; doi: 10.1038/sj.leu.2404366).

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  3. Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB . Cutting Edge: Deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J Immunol 2006; 176: 1316–1320.

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Correspondence to R B Clark.

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Wohlfert, E., Clark, R. Enhanced CD28 signaling may be a common mechanism underlying resistance to regulation. Leukemia 21, 175 (2007).

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