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Flt-3 internal tandem duplication hampers differentiation of AML blasts towards leukemic dendritic cells

Leukemia volume 20, pages 1892–1895 (2006)Cite this article

A Corrigendum to this article was published on 22 November 2006

In the search for new treatment modalities necessary to eradicate minimal residual disease cells in acute myeloid leukemia (AML), immunotherapy provides an attractive option.

AML blasts have proven to be able to differentiate into dendritic cell (DC)-like leukemic antigen-presenting cells (APC) under serum-free, good clinical practise, conditions with the use of cytokines or calcium ionophores (CI), thereby providing the unique opportunity to generate APC harbouring the full range of potential, still unidentified tumor antigens.1 In in vitro assays, cultured AML-DC have proven to fulfil all criteria necessary to elicit potent T-cell responses in vivo, such as migration towards lymph node associated chemokines, and induction of leukemia-specific activation of cytotoxic T cells.1, 2, 3

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Authors and Affiliations

  1. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands

    I Houtenbos, T M Westers, G J Ossenkoppele, A A van de Loosdrecht, C J Hess & Q Waisfisz

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  1. I Houtenbos
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  2. T M Westers
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  3. G J Ossenkoppele
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  4. A A van de Loosdrecht
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  5. C J Hess
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  6. Q Waisfisz
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Correspondence to A A van de Loosdrecht.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Houtenbos, I., Westers, T., Ossenkoppele, G. et al. Flt-3 internal tandem duplication hampers differentiation of AML blasts towards leukemic dendritic cells. Leukemia 20, 1892–1895 (2006). https://doi.org/10.1038/sj.leu.2404348

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