Figure 6 | Leukemia

Figure 6

From: Restoration of shp1 expression by 5-AZA-2′-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma

Figure 6

Transfection of NPM-ALK induced a partial downregulation of SHP1. GP293 cells were transfected with an empty vector or an NPM-ALK-expressing vector. Cells transfected with NPM-ALK showed evidence of STAT3 activation (i.e. expression of pSTAT3) and a partial decrease in SHP1 expression, which was shown to be a 32% reduction by densitometry analysis. A relatively slight decrease in the total STAT3 band was also detectable after NPM-ALK transfection.

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