This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis Open Access 18 October 2020
-
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Oncogene Open Access 15 February 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Accession codes
References
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183: 2283–2291.
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66: 649–661.
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269–271.
Pui CH, Evans WE . Acute lymphoblastic leukemia. N Engl J Med 1998; 339: 605–615.
Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K et al. Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia: analysis in adults and children. Leukemia 2005; 19: 1841–1843.
Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC . Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol 2004; 24: 9265–9273.
Marshall GM, Kwan E, Haber M, Brisco MJ, Sykes PJ, Morley AA et al. Characterization of clonal immunoglobulin heavy chain and I cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia. Leukemia 1995; 9: 1847–1850.
Acknowledgements
LF is supported by the UK Leukemia Research Fund and the Kay Kendall Leukaemia Fund.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mansour, M., Linch, D., Foroni, L. et al. High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. Leukemia 20, 537–539 (2006). https://doi.org/10.1038/sj.leu.2404101
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2404101
This article is cited by
-
Developing Targeted Therapies for T Cell Acute Lymphoblastic Leukemia/Lymphoma
Current Hematologic Malignancy Reports (2023)
-
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis (2020)
-
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition
Oncogene (2019)
-
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Oncogene (2016)
-
CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia
Leukemia (2016)