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Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
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References
Cros E, Jordheim L, Dumontet C, Galmarini CM . Problems related to resistance to cytarabine in acute myeloid leukemia. Leuk Lymphoma 2004; 45: 1123–1132.
Emanuel PD . Juvenile myelomonocytic leukemia. Curr Hematol Rep 2004; 3: 203–209.
Largaespada DA, Shaughnessy Jr JD, Jenkins NA, Copeland NG . Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. J Virol 1995; 69: 5095–5102.
Largaespada DA, Brannan CI, Jenkins NA, Copeland NG . Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat Genet 1996; 12: 137–143.
Lu D, Nounou R, Beran M, Estey E, Manshouri T, Kantarjian H et al. The prognostic significance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer 2003; 97: 441–449.
Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004; 428: 332–337.
Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K . The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci USA 2005; 102: 8573–8578.
Milella M, Kornblau SM, Andreeff M . The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies. Rev Clin Exp Hematol 2003; 7: 160–190.
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This work is supported by the Leukemia and Lymphoma Society of America (LLS 7019–04, Specialized Center of Research).
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Yin, B., Morgan, K., Hasz, D. et al. Nf1 gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways. Leukemia 20, 151–154 (2006). https://doi.org/10.1038/sj.leu.2404033
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DOI: https://doi.org/10.1038/sj.leu.2404033
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