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Expression of Tel-Aml1 transcript variants in pediatric acute lymphoblastic leukemia

Leukemia volume 20, pages 165–167 (2006)Cite this article

Translocation t(12;21)(p13;q22), associated with favorable prognosis, is one of the most frequent structural chromosomal aberrations found in pediatric B-lineage acute lymphoblastic leukemia (ALL). This aberration leads to the fusion of exon 5 of Tel gene with exons 2 or 3 of Aml1 gene and results in long and short transcripts of Tel-Aml1. The short variant is differed from long form by 39 base pairs, that reflects the loss of the exon 2 of Aml1 gene during rearrangement or in the process of alternative splicing.1

It is known that various splice-variants/transcripts of fusion genes can be associated with different clinical features. For example, leukemic clone expressing Bcr-Ablp210 is more responsive to Gleevec therapy comparing with Bcr-Ablp190 positive cells.2 There are data concerning differences in prognosis of patients with various transcripts of Pml-Rara, expressed in acute promyelocytic leukemia.3 Biological or clinical significance of various Tel-Aml1 transcripts is still unknown. Therefore, we evaluated expression of Tel-Aml1 transcript variants and their relationship to laboratory features of childhood ALL.

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References

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Acknowledgements

This project was funded by the project #B-736 of the International Science and Technology Center.

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Authors and Affiliations

  1. Belarusian Research Center for Pediatric Oncology and Hematology, Minsk region, Minsk, Belarus

    A M Kustanovich, M V Belevtsev, I V Stasevich, T V Savitskaya, R I Jutzkevich, N N Savva & O V Aleinikova

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  1. A M Kustanovich
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  2. M V Belevtsev
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  3. I V Stasevich
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  4. T V Savitskaya
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  5. R I Jutzkevich
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  6. N N Savva
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  7. O V Aleinikova
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Kustanovich, A., Belevtsev, M., Stasevich, I. et al. Expression of Tel-Aml1 transcript variants in pediatric acute lymphoblastic leukemia. Leukemia 20, 165–167 (2006). https://doi.org/10.1038/sj.leu.2404028

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