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PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation

Leukemia volume 19, pages 1692–1696 (2005)Cite this article

TO THE EDITOR

Many myeloproliferative disorders (MPDs) are due to constitutively activated tyrosine kinases (TK) that induce cell survival and proliferation. Chronic myeloid leukaemia (CML), which is associated with BCR-ABL fusion, is the most frequent typical MPD. Fusions of PDGFRB and FGFR1 with various partners have been found in atypical CML, chronic myelomonocytic leukaemia and other, unclassifiable, MPDs. A PCM1-JAK2 fusion was recently characterised in MPDs.1, 2 Mutation of the JAK2 kinase is frequent in polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis.3

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References

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Acknowledgements

This work has been supported by Institut Paoli-Calmettes, Inserm and grants from Laurette Fugain Association. VGB and BD were supported by a fellowship from Association pour la Recherche sur le Cancer and Société Française d’Hématologie, respectively.

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Author notes

  1. A Murati, V Gelsi-Boyer and J Adélaïde: AM, VG-B and JA have equally contributed to this work

Authors and Affiliations

  1. Département d’Oncologie Moléculaire, Institut de Cancérologie de Marseille, Institut Paoli-Calmettes and U599 Inserm, Marseille, France

    A Murati, V Gelsi-Boyer, J Adélaïde, A Letessier, B Delaval, D Birnbaum, M J Mozziconacci & M Chaffanet

  2. Département de BioPathologie, Institut Paoli-Calmettes, Marseille, France

    A Murati, V Gelsi-Boyer, L Xerri & M J Mozziconacci

  3. Université de la Méditerranée, Marseille, France

    V Gelsi-Boyer & L Xerri

  4. Laboratoire de Cytogénétique, Hôpital Saint-Antoine, Paris, France

    C Perot

  5. Laboratoire d’Hématologie, CHU Hôtel-Dieu, Institut de Biologie, Nantes, France

    P Talmant, L Lodé & R Garand

  6. Service d’Hématologie, Hôpital Henri Mondor, Créteil, France

    S Giraudier

  7. Service d’Hématologie, Centre Hospitalier du pays d’Aix, Aix-en-Provence, France

    V Brunel

  8. Laboratoire d’Hématologie, Hôpital Henri Mondor, Créteil, France

    M Imbert

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  1. A Murati
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Correspondence to M J Mozziconacci.

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Murati, A., Gelsi-Boyer, V., Adélaïde, J. et al. PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation. Leukemia 19, 1692–1696 (2005). https://doi.org/10.1038/sj.leu.2403879

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