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Reply to ‘C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12’ by Honczarenko et al

Leukemia volume 19, pages 1684–1685 (2005)Cite this article

TO THE EDITOR

The experiments performed by Dr Honczarenko et al1 confirmed our initial observations that C3 cleavage fragments (C3a and desArgC3a) modulate the responsiveness of hematopoietic cells to an SDF-1 gradient.2, 3 Accordingly, C3 cleavage fragments primed the responsiveness not only of bone marrow-derived Sca-1+ cells but interestingly also bone marrow-derived B-lymphocytic cells purified at different levels of development. Furthermore, in their letter, the authors supported our hypothesis4 that not C5L2 but another C3a and desArgC3a binding receptor may be involved in this phenomenon.

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References

  1. Honczarenko M, Lu B, Nicholson-Weller A, Gerard NP, Silberstein LE, Gerard C . C5L2 receptor is not involved in C3a/C3a-desArg mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia 2005, June 30 [E-pub ahead of print].

  2. Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells and C3a enhances homing-related responses of early hematopoietic cells to SDF-1. Blood 2003; 101: 3784–3793.

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  6. Wysoczynski M, Reca R, Ratajczak J, Kucia M, Shirvaikar N, Mills M et al. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem cells to an SDF-1 gradient. Blood 2005; 105: 40–48.

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  1. Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    M Z Ratajczak, R Reca & M Wysoczynski

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  1. M Z Ratajczak
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  2. R Reca
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  3. M Wysoczynski
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Correspondence to M Z Ratajczak.

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Ratajczak, M., Reca, R. & Wysoczynski, M. Reply to ‘C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12’ by Honczarenko et al. Leukemia 19, 1684–1685 (2005). https://doi.org/10.1038/sj.leu.2403863

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