Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1


  1. Creutzig U, Ritter J, Zimmermann M, Reinhardt D, Hermann J, Berthold F et al. Improved treatment results in high-risk pediatric acute myeloid leukemia patients after intensification with high-dose cytarabine and mitoxantrone: results of Study Acute Myeloid Leukemia – Berlin – Frankfurt – Munster 93. J Clin Oncol 2001; 19: 2705–2713.

    Article  CAS  Google Scholar 

  2. Creutzig U, Zimmermann M, Reinhardt D, Dworzak M, Stary J, Lehrnbecher T . Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98. J Clin Oncol 2004; 22: 4384–4393.

    Article  Google Scholar 

  3. Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR et al. Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. Blood 2001; 97: 3727–3732.

    Article  CAS  Google Scholar 

  4. Hann IM, Webb DK, Gibson BE, Harrison CJ . MRC trials in childhood acute myeloid leukaemia. Ann Hematol 2004; 83 (Suppl 1): S108–S112.

    PubMed  Google Scholar 

  5. Stevens RF, Hann IM, Wheatley K, Gray RG . Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party. Br J Haematol 1998; 101: 130–140.

    Article  CAS  Google Scholar 

  6. Dastugue N, Lafage-Pochitaloff M, Pages MP, Radford I, Bastard C, Talmant P et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Francais de Cytogenetique Hematologique (GFCH). Blood 2002; 100: 618–626.

    Article  CAS  Google Scholar 

  7. Duchayne E, Fenneteau O, Pages MP, Sainty D, Arnoulet C, Dastugue N et al. Acute megakaryoblastic leukaemia: a national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d’Hematologie Cellulaire (GFHC). Leuk Lymphoma 2003; 44: 49–58.

    Article  CAS  Google Scholar 

  8. Garderet L, Labopin M, Gorin NC, Polge E, Baruchel A, Meloni G et al. Hematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT). Blood 2005; 105: 405–409.

    Article  CAS  Google Scholar 

  9. Krance RA, Hurwitz CA, Head DR, Raimondi SC, Behm FG, Crews KR et al. Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases. J Clin Oncol 2001; 19: 2804–2811.

    Article  CAS  Google Scholar 

Download references


This work was supported by grants from the ‘Deutsche Krebshilfe’ (UC, JR), the ‘Deutsche José Carreras Leukämie Stiftung’ (UC, DR) and the ‘Leukemia & Lymphoma Society’ (DR, CL).

Author information

Authors and Affiliations


Corresponding author

Correspondence to D Reinhardt.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Reinhardt, D., Diekamp, S., Langebrake, C. et al. Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment. Leukemia 19, 1495–1496 (2005).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links