Table 2 Patients' cytogenetic features

From: Incidence and prognostic significance of karyotype abnormalities in de novo primary myelodysplastic syndromes: a study on 331 patients from a single institution

Total patients 331 (%)
Karyotype  
 Normal 125 (37.8)
 Abnormal 206 (62.2)
Chromosome defect and FAB:  
 RARS 22 (6.6)
 RA 62 (18.7)
 RAEB 82 (24.8)
 RAEB-t 40 (12.1)
Chromosome defect and IPSS score  
 Low 19 (5.7)
 Intermediate-1 61 (18.4)
 Intermediate-2 55 (16.6)
 High 71 (21.5)
Chromosome defects  
 Single 125 (37.7)
 Double 51 (15.4)
 Complex 30 (9.0)
IPSS cytogenetic categories a  
 Good 168 (50.7)
 Intermediate 107 (32.3)
 Poor 56 (17.0)
Chromosome most frequently rearranged  
 1q 7 (2.1)
 3q 13 (3.9)
 −5 7 (2.1)
 del(5q) 46 (13.9)
 −7 13 (3.9)
 del(7q) 26 (7.8)
 +8 23 (6.9)
 del(11q) 9 (2.7)
 del(11p) 9 (2.7)
 del(12p) 11 (3.3)
 der(17q) 7 (2.1)
 del(17p) 6 (1.8)
 del(20q) 14 (4.2)
Single defects  
 +1q 4 (1.2)
 3q abnormalities 10 (3.0)
 del(5) (q13q33) 16 (4.8)
 del(5) (q23q33) 14 (4.2)
 −7 9 (2.7)
 del(7) (q31q35) 15 (4.5)
 +8 16 (4.8)
 del(12p) 6 (1.8)
 del(17p) 4 (1.2)
 del(20q) 10 (3.0)
 −y 3 (0.9)
 Miscellaneous 18 (5.4)
  1. aGood=normal, −Y, del(5) (q13q33), del(5) (q23q33), del(20q) only; Intermediate=+8, various single and double defects; Poor=complex (≥ three defects), −7, del(7q).