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Maintained rules of development in a mouse B-cell tumor

Leukemia volume 19, pages 1278–1280 (2005)Cite this article

TO THE EDITOR

Two transgenic founders were generated (Figure 1b, left panel), both of which succumbed at 8 weeks of age to pronounced lymphosplenomegaly with histologically a ‘starry sky’ landscape reminiscent of human Burkitt's lymphoma (data not shown). Immunohistochemical and flow cytometric analysis confirmed that the tumors were of B-cell lineage (as determined by CD19 and B220 staining, data not shown). The expression of transgenic RNA was detected in tumor tissue by Northern blot (Figure 1b, right panels).

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Acknowledgements

We thank Dr Paul Szabo (Cornell) for suggestions on the choice of primers for VDJ rearrangement studies and discussions, and Dr Michael Kuehl (NCI/NIH) for comments on this paper.

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  1. M Affer, M Chesi & P L Bergsagel

    Present address: Mayo Clinic, Scottsdale, AZ, USA

Authors and Affiliations

  1. Department of Medicine, Division of Hematology and Medical Oncology, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA

    D F Robbiani, K Colon, M Affer, M Chesi & P L Bergsagel

  2. Immunology Program, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA

    D F Robbiani & P L Bergsagel

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  1. D F Robbiani
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Correspondence to P L Bergsagel.

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Robbiani, D., Colon, K., Affer, M. et al. Maintained rules of development in a mouse B-cell tumor. Leukemia 19, 1278–1280 (2005). https://doi.org/10.1038/sj.leu.2403774

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