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CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia

Leukemia volume 19, pages 1281–1284 (2005)Cite this article

TO THE EDITOR

In acute leukaemia, p15/p16 (CDKN2) deletions have been found with high frequencies in both adult and childhood acute lymphoblastic leukaemia (ALL) (>30%). In acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML) and myelodysplastic syndromes (MDS), very low frequencies of p15/p16 deletions have been observed (0–1%). However, the rates of p15 promoter hypermethylation, another frequent mechanism of p15/p16 inactivation, are very high in AML (70%), MDS (40%) and also precursor B-ALL and T-ALL (40%).1 Therefore, inactivation of this locus is thought to play an important role in leukaemogenesis and could have important clinical significance.

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Figure 1

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Acknowledgements

We thank the cytogenetic technicians of our laboratory for the considerable effort put into preparing the metaphases and for their assistance in analysing the karyotypes. This study was partly funded by the Association for International Cancer Research (Grant no. 99-111).

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  1. A Hagemeijer

    Present address: Centre for Human Genetics, Catholic University of Leuven, Leuven, Belgium

Authors and Affiliations

  1. Department of Genetics, Erasmus MC, Rotterdam, The Netherlands

    L J C M van Zutven, E van Drunen, A Hagemeijer & R M Slater

  2. Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands

    E van Drunen, M M Wattel, R M Slater & H B Beverloo

  3. Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands

    J M de Bont, M L Den Boer & R Pieters

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Correspondence to H B Beverloo.

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van Zutven, L., van Drunen, E., de Bont, J. et al. CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia. Leukemia 19, 1281–1284 (2005). https://doi.org/10.1038/sj.leu.2403769

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