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Imatinib induces apoptosis in CLL lymphocytes with high expression of Par-4

Leukemia volume 19, pages 1103–1105 (2005)Cite this article

TO THE EDITOR

In conclusion, these results support the notion that Imatinib applied in clinically achievable concentrations may sensitize towards or even induce apoptosis by interaction with c-abl in cells of lymphatic origin lacking BCR-ABL, c-KIT or PDGFR but that response to this mechanism may dependent on certain cellular conditions which segregate responders from nonresponders such as, for example, functioning of proapoptotic pathways involving Par-4.

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Acknowledgements

This study was supported by a grant from the Adolf Messer Stiftung, Koenigsstein, Germany.

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Authors and Affiliations

  1. Hematology and Oncology, University Hospital, Frankfurt/Main, Germany

    K U Chow, D Nowak, W Hofmann & B Schneider

  2. Department of Hematology and Oncology, University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany

    W-K Hofmann

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  1. K U Chow
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  2. D Nowak
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  3. W Hofmann
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Correspondence to K U Chow.

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Chow, K., Nowak, D., Hofmann, W. et al. Imatinib induces apoptosis in CLL lymphocytes with high expression of Par-4. Leukemia 19, 1103–1105 (2005). https://doi.org/10.1038/sj.leu.2403739

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