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Transfer of genomics information to flow cytometry: expression of CD27 and CD44 discriminates subtypes of acute lymphoblastic leukemia

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  1. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133–143.

    Article  CAS  Google Scholar 

  2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41–47.

    Article  CAS  Google Scholar 

  3. Ross ME, Zhou X, Song G, Shurtleff SA, Girtman K, Williams WK et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003; 102: 2951–2959.

    Article  CAS  Google Scholar 

  4. Fine BM, Stanulla M, Schrappe M, Ho M, Viehmann S, Harbott J et al. Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia. Blood 2004; 103: 1043–1049.

    Article  CAS  Google Scholar 

  5. Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S et al. Pediatric acute lymphoblastic leukemia. Hematology (Am Soc Hematol Educ Program) 2003, 102–131.

  6. Hrusak O, Porwit-MacDonald A . Antigen expression patterns reflecting genotype of acute leukemias. Leukemia 2002; 16: 1233–1258.

    Article  CAS  Google Scholar 

  7. Chen JS, Coustan-Smith E, Suzuki T, Neale GA, Mihara K, Pui CH et al. Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia. Blood 2001; 97: 2115–2120.

    Article  CAS  Google Scholar 

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We thank the cytometric technicians Jana Ridoskova, Klara Pospisilova and Lucie Gondorcinova, and the molecular genetic technicians Katka Muzikova and Leona Reznickova and Marketa Kalinova. MV highly appreciates the practical and theoretical experience in the laboratory of Z Trajanoski (Institute of Biomedical Engineering and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Austria), as well as the friendly atmosphere. The collaboration of all Czech Pediatric Hematology (CPH) centers (leaders: B Blazek (Ostrava), Z Cerna (Plzen), J Hak (Hradec Kralove), Y Jabali (Ceske Budejovice), V Mihal (Olomouc), D Prochazkova (Usti nad Labem), J Stary (Praha) and J Sterba (Brno)) is appreciated. The work was supported by Grants Nos. GA UK 80/2004, MSM0021620813, IGA MZ CR 7430-3 and 6929-3.

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Correspondence to O Hrusak.

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Vaskova, M., Mejstrikova, E., Kalina, T. et al. Transfer of genomics information to flow cytometry: expression of CD27 and CD44 discriminates subtypes of acute lymphoblastic leukemia. Leukemia 19, 876–878 (2005).

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