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Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib

Leukemia volume 19, pages 458–460 (2005)Cite this article

TO THE EDITOR

Imatinib is a potent inhibitor of the BCR-ABL tyrosine kinase. Treatment of chronic myelogenous leukemia (CML) in different stages of disease has shown its efficacy and superiority to conventional therapies. Beside inhibition of BCR-ABL, imatinib also has inhibitory effects on other tyrosine kinases such as wild-type ABL, c-KIT and platelet-derived growth factor receptors (PDGF-R) alpha and beta. ABL interacts with several proteins involved in DNA repair mechanisms such as p73, DNA-PK and RAD51.1,2 C-KIT plays an essential role in differentiation and proliferation of hematopoietic stem cells.3 PDGF-R is expressed by bone marrow stromal cells that are constituents of the hematopoietic microenvironment. Inhibition of ABL, c-KIT or PDGF-R might therefore result in functional disturbance of hematopoiesis or even in secondary karyotypic abnormalities observed in Philadelphia (Ph)-negative hematopoiesis during imatinib therapy.4,5

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Acknowledgements

This work was supported by the Leukämie Liga e.V., Düsseldorf.

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Authors and Affiliations

  1. Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany

    F Neumann, N Teutsch, S Kliszewski, S Bork, U Steidl, N Schimkus, N Roes, U Germing, N Gattermann, R Haas & R Kronenwett

  2. Theoretical Bioinformatics, German Cancer Research Centre, Heidelberg, Germany

    B Brors & R Eils

  3. Department of Human Genetics and Anthropology, Heinrich Heine University, Düsseldorf, Germany

    B Hildebrandt & B Royer-Pokora

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  1. F Neumann
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Correspondence to R Kronenwett.

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Neumann, F., Teutsch, N., Kliszewski, S. et al. Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib. Leukemia 19, 458–460 (2005). https://doi.org/10.1038/sj.leu.2403615

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  • DOI: https://doi.org/10.1038/sj.leu.2403615

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