Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Spotlight Correspondence
  • Published:

Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha

Leukemia volume 19, pages 460–463 (2005)Cite this article

TO THE EDITOR,

The tyrosine kinase inhibitor imatinib mesylate was introduced in the treatment of chronic myeloid leukemia (CML) in 1998. In 2002, there were first reports about the occurrence of clonal changes in Philadelphia negative (Ph−) cells during imatinib treatment. So far, more than 80 cases have been reported.1

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

References

  1. Terre C, Eclache V, Rousselot P, Imbert M, Charrin C, Gervais C et al. Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia. Leukemia 2004; 18: 1340–1346.

    Article  CAS  Google Scholar 

  2. Schoch C, Haferlach T, Kern W, Schnittger S, Berger U, Hehlmann R et al. Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate. Leukemia 2003; 17: 461–463.

    Article  CAS  Google Scholar 

  3. Schoch C, Schnittger S, Bursch S, Gerstner D, Hochhaus A, Berger U et al. Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: a study on 350 cases. Leukemia 2002; 16: 53–59.

    Article  CAS  Google Scholar 

  4. Bumm T, Muller C, Al Ali HK, Krohn K, Shepherd P, Schmidt E et al. Emergence of clonal cytogenetic abnormalities in Ph− cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101: 1941–1949.

    Article  CAS  Google Scholar 

  5. Meeus P, Demuynck H, Martiat P, Michaux L, Wouters E, Hagemeijer A . Sustained, clonal karyotype abnormalities in the Philadelphia chromosome negative cells of CML patients successfully treated with imatinib. Leukemia 2003; 17: 465–467.

    Article  CAS  Google Scholar 

  6. Ariyama T, Inazawa J, Uemura Y, Kakazu N, Maekawa T, Urase F et al. Clonal origin of Philadelphia-chromosome negative cells with trisomy-8 appearing during the course of alpha-interferon therapy for Ph positive chronic myelocytic-leukemia. Cancer Genet Cytogenet 1995; 81: 20–23.

    Article  CAS  Google Scholar 

  7. Medina J, Kantarjian H, Talpaz M, O'Brien S, Garcia-Manero G, Giles F et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 2003; 98: 1905–1911.

    Article  CAS  Google Scholar 

  8. O'Dwyer ME, Gatter KM, Loriaux M, Druker BJ, Olson SB, Magenis RE et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003; 17: 481–487.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Leukemia Diagnostics, Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany

    U Bacher, W Hiddemann, T Haferlach & C Schoch

  2. III. Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität, Heidelberg, Germany

    A Hochhaus, U Berger & R Hehlmann

Authors
  1. U Bacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Hochhaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W Hiddemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R Hehlmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Haferlach
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C Schoch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U Bacher.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bacher, U., Hochhaus, A., Berger, U. et al. Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha. Leukemia 19, 460–463 (2005). https://doi.org/10.1038/sj.leu.2403607

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403607

This article is cited by

Search

Advanced search

Quick links