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New insight into the molecular mechanisms of MLL-associated leukemia

Leukemia volume 19, pages 183–190 (2005)Cite this article

Abstract

Rearrangements of the MLL gene (ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in adult and pediatric cases of primary acute leukemias and also found in cases of therapy-related secondary leukemias. Studies on mouse models of MLL translocation and cell lines containing MLL rearrangements showed that the MLL gene linked chromosomal rearrangements to cellular differentiation and tumor tropism. Moreover, recent structural/functional studies on MLL and aberrant MLL proteins provided new clues and suggested that different mechanisms might be included in leukemogenesis by MLL rearrangements. The connection between these different mechanisms will help us understand globally how aberrant MLL oncogenes affect the normal cellular processes at molecular level.

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Acknowledgements

We thank Dr Gong-Hong Wei and other colleagues for helpful discussion and critical reading of the manuscript. We apologize for any errors or omissions in this review. This work was supported by a grant from the National Natural Science Foundation of China (N0. 30393110).

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  1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, PR China

    Z-Y Li, D-P Liu & C-C Liang

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Li, ZY., Liu, DP. & Liang, CC. New insight into the molecular mechanisms of MLL-associated leukemia. Leukemia 19, 183–190 (2005). https://doi.org/10.1038/sj.leu.2403602

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