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Upregulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL

Leukemia volume 19, pages 318–319 (2005)Cite this article

TO THE EDITOR

The (12;21)(p13;q22) translocation resulting in TEL/AML1 gene fusion is generally associated with a good prognosis and a high cellular sensitivity to L-asparaginase (L-Asp).1, 2 L-Asp hydrolyses asparagine and glutamine resulting into cellular depletion of these amino acids.

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Authors and Affiliations

  1. Division of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands

    W A G Stams, M L den Boer & R Pieters

  2. Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    H B Beverloo

  3. Dutch Childhood Oncology Group, The Hague, The Netherlands

    E R van Wering & R Pieters

Authors
  1. W A G Stams
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  2. M L den Boer
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  3. H B Beverloo
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  4. E R van Wering
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  5. R Pieters
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Correspondence to M L den Boer.

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Stams, W., den Boer, M., Beverloo, H. et al. Upregulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL. Leukemia 19, 318–319 (2005). https://doi.org/10.1038/sj.leu.2403573

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  • DOI: https://doi.org/10.1038/sj.leu.2403573

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