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A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia

Leukemia volume 19, pages 145–148 (2005)Cite this article

TO THE EDITOR

This is the first time, to our knowledge, NUP98 is fused to PRRX2 by a t(9;11)(q34;p15), and even PRRX2 is involved in malignancy. NUP98 gene has been found at breakpoints of several distinct recurrent translocations in patients with both de novo and therapy-related MDS/AML and T-ALL. The report from the international workshop of Chicago in 2002 considered 11p15 rearrangements as rare (3.3%) recurring balanced chromosome abnormality in therapy-related leukemia, suggesting that genotoxic chemotherapeutic agents may play an important role in generating chromosomal rearrangements involving NUP98.

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Acknowledgements

We thank Seiamak BAHRAM for reading the manuscript, and Mariano ROCCHI for providing BACs and PACs.

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Authors and Affiliations

  1. Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Avenue Molière, Strasbourg, France

    C Gervais, L Mauvieux, C Hélias, S Struski, V Leymarie & M Lessard

  2. Laboratoire d'Hématologie cellulaire, Faculté de Médecine de Strasbourg, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    C Gervais, L Mauvieux, N Perrusson & M Lessard

  3. Département d'Onco-Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    B Lioure

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  1. C Gervais
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Correspondence to M Lessard.

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Gervais, C., Mauvieux, L., Perrusson, N. et al. A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Leukemia 19, 145–148 (2005). https://doi.org/10.1038/sj.leu.2403565

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