Table 1 Clinical characteristics of asymptomatic IgM-MGs and IgM-related disorders at diagnosis

From: Clinical characteristics and factors predicting evolution of asymptomatic IgM monoclonal gammopathies and IgM-related disorders

Characteristic Asymptomatic IgM-MG (n=384) IgM-related disorder (n=74) P-value
Males/females 228/156 27/47 0.0005
Age (Years)    0.006
 Median 66 (384) 62 (74)  
 Range 23-91 27-81  
κ/λ 280/95 (381) 70/4 (74) 0.0001
Serum MC (g/dl)    0.0001
 Median 0.9 (367) 0.5 (66)  
 Range 0.13-6.62 0.11-3.60  
Detectable BJ proteinuria, % of Pts 17.6 (336) 8.6 (70) 0.092
Urine MC (mg/24 h)   
 Median 180 (33) 50 (1)  
 Range 26-2,800
One normal Ig reduction, % of Pts 12.6 (356) 11.1 (63) 0.8
Two normal Ig reduction, % of Pts 3.1 (356) 0 (63) 0.3
Hb (g/dl)    0.013
 Median 14 (369) 13.5 (72)  
 Range 8.1-17.9 8.7-18.7  
ANC (× 10 9 /l)    0.061
 Median 3.76 (311) 3.48 (72)  
 Range 0.18-11.55 1.67-8.62  
Platelet count (× 10 9 /l)    
 Median 240 (317) 218 (65) 0.2
 Range 110-697 105-680  
ALC (× 10 9 /l)    0.3
 Median 2.0 (309) 1.9 (72)  
 Range 0.3-32.8 0.6-12.0  
ESR (mm/h)    0.9
 Median 27 (336) 31 (69)  
 Range 2-138 3-125  
β2-microglobulin (μg/ml)    0.0004
 Median 2.0 (288) 2.3 (37)  
 Range 0.1-9.0 0.9-7.8  
BM LP Infiltration (%)    0.05
 Median 6 (213) 10 (31)  
 Range 0-90 0-30  
Follow-up (months)    0.011
Median 45 (384) 60 (74)  
 Range 12-233 13-195  
  1. The number of Pts in each parameter is reported in parenthesis. Prognostic Index= 1.2636 X 1 - 0.2684 X 2 + 2.4165 X 3 - 0.1190 X 4 + 0.4071 X 5 .